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Short Chain Fatty Acid Combination Treatment Protects Against 6-Ohda And Wt Α-Synuclein Induced Decreases In Neurite Growth In In Vitro Models Of Parkinson’S Disease., Alex Morris
ORBioM (Open Research BioSciences Meeting)
Background
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron degeneration. This degeneration is partly driven by over expression of α-synuclein (α-syn) and development of α-syn aggregates known as Lewy bodies throughout the substantia nigra. As well as motor dysfunction, PD presents with several chronic gastrointestinal comorbidities, which cause a decline of gut microbial diversity and microbially derived short chain fatty acids (SCFAs). Recent in vivo studies have shown SCFAs to be neuroprotective in various degenerative disease states, suggesting that SCFAs may protect against dopaminergic degeneration.
Methods
Human neuroblastoma SH-SY5Y cells were used as a model of human …
Short Chain Fatty Acid Combination Treatment Protects Against 6-Ohda Induced Decrease In Neurite Growth In An In Vitro Model Of Parkinson’S Disease., Alex Morris
ORBioM (Open Research BioSciences Meeting)
Title: Short chain fatty acid combination treatment protects against 6-OHDA induced decrease in neurite growth in an in vitro model of Parkinson’s disease.
Authors: Alex Morris1, Louise M. Collins1,2,3, Gerard W. O’Keeffe2, Caitriona M. Guinane1
1 Department of Biological Sciences, Munster Technological University (MTU), Cork, Ireland.
2 Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland.
3 Department of Physiology, University College Cork, Cork, Ireland.
Background: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron degeneration. This leads to motor dysfunction which is accompanied by gastrointestinal comorbidities such as constipation …