Life Sciences Commons^™

Nanoparticle Exposure Activates An Inositol Triphosphate Receptor-Dependent Elevation Of Reactive Oxygen Species And Apoptosis In Human Alveolar Lung Cells, Briana Manes, Sarah Alvarado

Seaver College Research And Scholarly Achievement Symposium

The signaling of cell stress in response to organelle dysfunction, toxin exposure, and mutation is complex; generating responses that can include adaptation, or in severe cases, cellular apoptosis. Nanoparticles (20-100 nm diameter) have been shown to induce cell stress in lung cells, potentially identifying a cause of lung disease in areas with high levels of particulate-based air pollution. This study examines the effect of carbon black (CB) and titanium dioxide (TiO2) nanoparticles on stress signaling and apoptosis in cultured A549 human alveolar epithelial cells. CB and TiO2 powders were dispersed throughout a buffered solution containing bovine serum albumin using probe …