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Targeting Cxcr4 With Ctce-9908 Inhibits Prostate Tumor Metastasis, Donald Wong, Pridvi Kandagatla, Walter Korz, Sreenivasa R. Chinni
Targeting Cxcr4 With Ctce-9908 Inhibits Prostate Tumor Metastasis, Donald Wong, Pridvi Kandagatla, Walter Korz, Sreenivasa R. Chinni
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
CXCL12/CXCR4 transactivation of epidermal growth factor family receptors in lipid raft membrane microdomains on cell surface is thought to mediate tumor growth and subsequent development of metastatic disease. CTCE-9908 is a known inhibitor of CXCR4. Herein, we tested the efficacy of CTCE-9908 in inhibiting prostate cancer cell growth, invasion, and metastasis.
Methods
We used a panel ofin vitroassays utilizing human prostate cancer cell lines and anin vivoorthotopic prostate cancer model to assess the anti-tumoral activity of CTCE-9908.
Results
We demonstrated that (a) CTCE-9908 treatment resulted in no significant change in the growth of PC-3 and C4-2B cells; (b) …