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An In Vivo Study Of Cortical Dynein Dynamics And Its Contribution To Microtubule Sliding In The Midzone, Heather M. Jordan
An In Vivo Study Of Cortical Dynein Dynamics And Its Contribution To Microtubule Sliding In The Midzone, Heather M. Jordan
Masters Theses
In LLC-Pk1 cells, and most cultured mammalian cells, cell division is highly regulated to achieve equal sized daughter cells. During this process, duplicated centrosomes separate and establish a bipolar array called the mitotic spindle. The mitotic spindle is responsible for aligning the chromosomes at the metaphase plate, and separating sister chromatids during anaphase. Spindle positioning and elongation are thought to be driven by the interaction between dynamic astral microtubules and cortical dynein. Extensive research has revealed that dynein is anchored to the cortex via the highly conserved NuMA/LGN/Gαi ternary complex in metaphase and the additional PIP/PIP2/NuMA, or 4.1G/R/NuMA, pathways during …