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Investigation Into The Function Of Endothelial Cells And Their Signaling In Early Salivary Gland Development, Hae Ryong Kwon
Investigation Into The Function Of Endothelial Cells And Their Signaling In Early Salivary Gland Development, Hae Ryong Kwon
Legacy Theses & Dissertations (2009 - 2024)
Functional vasculature regulates organ formation and regeneration. Perfusion-independent and nutrition-independent endothelial regulation of epithelial patterning is of considerable interest for application in restoring parenchymal function. During murine submandibular salivary gland development, the vasculature co-develops with the epithelium; however, it is still unknown if the vasculature has instructive effects on the epithelium. A systems biological study revealed that endothelial genes are enriched in epithelial clefts, suggesting a potential involvement of endothelial cells in early morphogenesis. Using immunodepletion of the endothelial cells from the mesenchyme of reconstituted glands, a requirement for endothelial cells in epithelial patterning was demonstrated. Specifically, lobule formation was …