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Studies Of Dynein Anchoring Protein In Budding Yeast Saccharomyces Cerevisiae, Safia Omer
Studies Of Dynein Anchoring Protein In Budding Yeast Saccharomyces Cerevisiae, Safia Omer
Doctoral Dissertations
Inheritance of equal genomic content is vital for cellular growth and survival. During cell division, the mitotic spindle is built to ensure equal chromosome segregation between dividing cells. Fidelity of segregation is achieved by the precise positioning of the mitotic spindle by force generators located at the cell cortex where they exert pulling on microtubule (MT). Cortical dynein, a minus end directed motor, generates pulling forces via microtubule end-on capture-shrinkage and lateral MT sliding mechanisms. In Saccharomyces cerevisiae, the dynein attachment molecule Num1 interacts with plasma membrane (PM), endoplasmic reticulum (ER), and mitochondria to facilitate spindle positioning across the …