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The Identification And Characterization Of A Group Of Er Tpr-Containing Adapter Proteins, Johan C. Sunryd

Doctoral Dissertations

The endoplasmic reticulum (ER) is an organelle responsible for a variety of functions in all eukaryotic cells. Some of these functions are localized to specific regions in the ER, such as the ribosome-studded rough ER sheets or the ribosome-free smooth ER sheets. The smooth ER sheets have the ability to form ER tubules, which extend throughout the cell and make contact with other organelles. In order to accommodate these localized functional regions, a certain degree of heterogeneity and compartmentalization into sub-domains exists within the ER. Since the ER membrane and lumen are contiguous, the compartmentalization of the ER into sub-domain …