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The Mechanism Of The Gastric Epithelial Stem Cell Response To Metaplastic Injury, Shradha Sachin Khurana
The Mechanism Of The Gastric Epithelial Stem Cell Response To Metaplastic Injury, Shradha Sachin Khurana
All Theses and Dissertations (ETDs)
Almost nothing is known about the identity of the epithelial stem cell of the gastric corpus, either during normal turnover or in response to injury. Our lab has shown that injection of the selective estrogen receptor modulator tamoxifen leads to near complete atrophy of parietal cells by 3 days and induces expansion of an undifferentiated cell population within the normal stem cell niche in the isthmus of the gastric unit. Here we show that CD44 labels the membranes of such undifferentiated isthmal cells, both in the normal gastric epithelium and when those cells expand fourfold upon injury with tamoxifen. Loss …