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The Sumo-Targeted Ubiquitin Ligase Rnf4 Regulates The Localization And Function Of The Htlv-1 Oncoprotein Tax, Kimberly A. Fryrear, Xin Guo, Oliver Kerscher, O John Semmes
The Sumo-Targeted Ubiquitin Ligase Rnf4 Regulates The Localization And Function Of The Htlv-1 Oncoprotein Tax, Kimberly A. Fryrear, Xin Guo, Oliver Kerscher, O John Semmes
Arts & Sciences Articles
The Really Interesting New Gene (RING) Finger Protein 4 (RNF4) represents a class of ubiquitin ligases that target Small Ubiquitin-like Modifier (SUMO)–modified proteins for ubiquitin modification. To date, the regulatory function of RNF4 appears to be ubiquitin-mediated degradation of sumoylated cellular proteins. In the present study, we show that the Human T-cell Leukemia Virus Type 1 (HTLV-1) oncoprotein Tax is a substrate for RNF4 both in vivo and in vitro. We mapped the RNF4-binding site to a region adjacent to the Tax ubiquitin/SUMO modification sites K280/K284. Interestingly, RNF4 modification of Tax protein results in relocalization of the oncoprotein from the …