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Full-Text Articles in Life Sciences
Exploring The Connection Between The Spontaneous Regression Seen In Neuroblastomas, Hypertumors, And Reactive Oxygen Species, Shahad Musa, Manitha Mulpuru
Exploring The Connection Between The Spontaneous Regression Seen In Neuroblastomas, Hypertumors, And Reactive Oxygen Species, Shahad Musa, Manitha Mulpuru
AUCTUS: The Journal of Undergraduate Research and Creative Scholarship
Peto’s Paradox is defined as the lack of correlation between larger animals and cancer risk. Under the assumption that all cells have equal risk of becoming cancerous, larger animals should have greater rates of cancer. However, the inverse is true. Determining the cause of this variation may allow a supplemental approach to cancer treatment. A combination of two reasons may account for this correlation including hypertumors and metabolism. Hypertumors, or cheater cells, are hypothesized to suppress cancer growth through spontaneous autophagic degradation and overexpression of the RAS g-protein. Both of these characteristics are exhibited in Neuroblastomas. An anticancer drug used …
Using The Frog Epidermis To Uncover Desmosome Function And Regulation In The Developing Embryo, Navaneetha Krishnan Bharathan
Using The Frog Epidermis To Uncover Desmosome Function And Regulation In The Developing Embryo, Navaneetha Krishnan Bharathan
Theses and Dissertations
The desmosome is one of the major cell adhesion junctions found in the epithelia, heart, and hair follicle. Described as a “rivet” that hold cells together, it provides these tissues with the integrity to withstand the tremendous forces they face in everyday life. Defects in this junction can lead to devastating diseases where patients are susceptible to skin infections and cardiovascular defects. Limited treatments exist for diseases of the desmosome, and strategies do not target all symptoms. Therefore, delineating the function and regulation of desmosomes is of paramount importance for the development of prevention and treatment strategies. The Xenopus laevis …