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Exploring The Impact Of Pqn-75 And Glh-1/Vasa On Germline Development, Maintenance, And Gsc Reprogramming Using Caenorhabditis Elegans As A Model, Jesse D. Rochester
Exploring The Impact Of Pqn-75 And Glh-1/Vasa On Germline Development, Maintenance, And Gsc Reprogramming Using Caenorhabditis Elegans As A Model, Jesse D. Rochester
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This thesis combines research on PQN-75 expression, functional motifs of GLH-1/Vasa, and germ granule components in Caenorhabditis elegans to provide a comprehensive understanding of germline development, maintenance, and reprogramming, while also examining the role of pharyngeal gland cells in stress resistance and thermotolerance. In C. elegans, pharyngeal gland cells secrete mucin-like proteins, such as PQN-75, with similarities to human PRB2. The expression of PQN-75 in gland cells confers stress resistance and thermotolerance but does not affect fertility, instead it plays a role in the organism's ability to adapt to varying environmental conditions. While, GLH-1/Vasa, an ATP-dependent DEAD-box helicase, plays …