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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
A Mechanistic Study On The Non-Genotoxic Carcinogenicity Of The Food Contaminant Semicarbazide, Daniel P. Fitzpatrick
A Mechanistic Study On The Non-Genotoxic Carcinogenicity Of The Food Contaminant Semicarbazide, Daniel P. Fitzpatrick
SURE Journal: Science Undergraduate Research Experience Journal
Semicarbazide was brought to the forefront of scientific discussions by the scientific community in the early 2000’s as the substance was discovered in several food products from both synthetic and natural sources. Although semicarbazide was processed through several toxicological assays and classified as a non-genotoxic carcinogen, underwhelming amounts of toxicological data exists for the compound. The present study is one of the first in-vitro studies to examine the relationship between sub-pathophysiological concentrations of reactive oxygen species and the anomalous non-genotoxic carcinogenicity induced by semicarbazide through the upregulation of intracellular signalling pathways. A novel finding of the present study was where …
Bioavailability And Modes Of Action Of Novel Metal Based Phenanthroline Drugs, Tadhg O’Leary
Bioavailability And Modes Of Action Of Novel Metal Based Phenanthroline Drugs, Tadhg O’Leary
Doctoral
Metal-basedcompounds have been utilised as chemotherapeutic agents for the last four decades due to their well-documented and clinically relevant anti-tumour properties.Acquired resistance is a challenge for the clinical use of these compounds and there is a continuing need to search for potential new therapeutic agents. Herein, the potential of two metal-basedcompounds containing chelated1,10-phenanthroline (1,10-Phen), one manganese-based (CMPD 73)andonecopper-based (CMPD 74), to act as novel therapeutic agents is explored.CMPD 73 displayed high micromolar (IC50>100μM) cytotoxic properties againstvarious cell systems but interestingly displayed increased cytotoxicity against ovarian (A2780), lung (A549) and cisplatin resistant mesothelioma cells(IC5040-50μM). CMPD 74 was equally cytotoxic against …
3d Mammalian Cell Culture Models In Toxicology Testing, Janith Wanigasekara, Brijesh K. Tiwari, James Curtin
3d Mammalian Cell Culture Models In Toxicology Testing, Janith Wanigasekara, Brijesh K. Tiwari, James Curtin
Articles
3D cell culture can be successfully used as an alternative to laboratory animals, and as a cost effective and time-saving tissue culture technique, which also reduces the trial period for drug testing.
Cold Atmospheric Plasma Induces Silver Nanoparticle Uptake, Oxidative Dissolution And Enhanced Cytotoxicity In Glioblastoma Multiforme Cells, Eline Manaloto, Aoife Gowen, Anna Lesniak, Zhonglei He, Alan Casey, Patrick J. Cullen, James Curtin
Cold Atmospheric Plasma Induces Silver Nanoparticle Uptake, Oxidative Dissolution And Enhanced Cytotoxicity In Glioblastoma Multiforme Cells, Eline Manaloto, Aoife Gowen, Anna Lesniak, Zhonglei He, Alan Casey, Patrick J. Cullen, James Curtin
Articles
Silver nanoparticles (AgNP) emerged as a promising reagent for cancer therapy with oxidative stress implicated in the toxicity. Meanwhile, studies reported cold atmospheric plasma (CAP) generation of reactive oxygen and nitrogen species has selectivity towards cancer cells. Gold nanoparticles display synergistic cytotoxicity when combined with CAP against cancer cells but there is a paucity of information using AgNP, prompting to investigate the combined effects of CAP using dielectric barrier discharge system (voltage of 75 kV, current is 62.5 mA, duty cycle of 7.5kVA and input frequency of 50–60Hz) and 10 nm PVA-coated AgNP using U373MG Glioblastoma Multiforme cells. Cytotoxicity in …
Optimisation Of Estrogen Receptor Subtype-Selectivity Of A 4-Aryl-4h-Chromene Scaffold Previously Identified By Virtual Screening, Miriam Carr, Andrew Knox, Daniel Nevin, Niamh O'Boyle, Shu Wang, Billy Egan, Thomas Mccabe, Brendan Twamley, Daniela Zisterer, David Lloyd, Mary Meegan
Optimisation Of Estrogen Receptor Subtype-Selectivity Of A 4-Aryl-4h-Chromene Scaffold Previously Identified By Virtual Screening, Miriam Carr, Andrew Knox, Daniel Nevin, Niamh O'Boyle, Shu Wang, Billy Egan, Thomas Mccabe, Brendan Twamley, Daniela Zisterer, David Lloyd, Mary Meegan
Articles
4-Aryl-4H-Chromene derivatives have been previously shown to exhibit anti-proliferative, apoptotic and anti-angiogenic activity in a variety of tumor models in vitro and in vivo generally via activation of caspases through inhibition of tubulin polymerisation. We have previously identified by Virtual Screening (VS) a 4-aryl-4H-chromene scaffold, of which two examples were shown to bind Estrogen Receptor α and β with low nanomolar affinity and <20-fold selectivity for α over β and low micromolar anti-proliferative activity in the MCF-7 cell line. Thus, using the 4-aryl-4H-chromene scaffold as a starting point, a series of compounds with a range of basic arylethers at C-4 and modifications at the C3-ester substituent of the benzopyran ring were synthesised, producing some potent ER antagonists in the MCF-7 cell line which were highly selective for ERα (compound 35; 350-fold selectivity) or ERβ (compound 42; 170-fold selectivity).
Development Of Methodologies For Raman Spectral Analysis Of Human Saliva For Detection Of Oral Cancer, Genecy Calado
Development Of Methodologies For Raman Spectral Analysis Of Human Saliva For Detection Of Oral Cancer, Genecy Calado
Doctoral
Oral cancer is one of the most common malignancies worldwide, with over 350,000 to 400,000 new cases reported each year. Early detection, followed by appropriate treatment, can increase cure rates to 80 or 90%, and greatly improve the quality of life by minimising extensive, debilitating treatments. Usually, the clinical diagnosis of most head and neck neoplasms, including oral cancer, is performed through time-consuming and invasive biopsies followed by histological examination of the excised tissue and may present psychological trauma and risk of infection to patients. In addition, histological grading can be subjective, as it is based on subtle morphological changes. …
Forscells: 40-Days Fixed Prepared Reagent For Detection Of Anti-Forssman Inhumans, Sofia Ferreira, Cristiana Mourato, Alyssa Corpuz, Sofia Galvão, Camilla Hesse, Clara Rocha, Carlos Jesus, Fernando Mendes
Forscells: 40-Days Fixed Prepared Reagent For Detection Of Anti-Forssman Inhumans, Sofia Ferreira, Cristiana Mourato, Alyssa Corpuz, Sofia Galvão, Camilla Hesse, Clara Rocha, Carlos Jesus, Fernando Mendes
Articles
In 2012, the FORS system was accepted by the International Society of Blood Transfusion as the 31st blood group system. Forssman (Fs) antigen (Ag) expression is most commonly found on sheep red blood cells (RBC) but rare in human RBC. Anti-Fs antibodies (Ab) are naturally occurring in human sera and are predominantly IgM but they can also be IgG. To this day, the global prevalence of the FORS system is unknown. Currently, there is a lack of natural FORS1-positive RBC available to use for anti-Fs screening in large populations. This study was designed to produce FORS1-positive cells viable for …