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Hair-Cell-Specific Genes In The Embryonic Chicken Inner Ear By Overexpression, Eric S. Traub, Donna Fekete
Hair-Cell-Specific Genes In The Embryonic Chicken Inner Ear By Overexpression, Eric S. Traub, Donna Fekete
The Summer Undergraduate Research Fellowship (SURF) Symposium
The inner ear houses organs used for hearing and balance that use hair cells to accomplish their tasks. Inner ear development remains to be fully understood, and advancing knowledge in development could lead to therapies and treatments for hearing problems. A gene called Atoh1 is necessary for hair cell formation and has been shown to increase hair cell number when overexpressed. Importantly, microRNAs from the 183 family (miRs-183, -182, and -96) are also expressed in developing hair cells. MicroRNAs are small RNA molecules that bind to messenger RNAs and prevent translation. MicroRNAs have been associated with cellular functions such as …