Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Aerobic glycolysis (1)
- Antibody (1)
- Basigin (1)
- Cancer (1)
- Cancer cell metabolism (1)
-
- Cd147 (1)
- Chlorotoxin (1)
- EMMPRIN (1)
- GBM (1)
- GLUT1 (1)
- Glioblastoma (1)
- Glioblastoma Treatment (1)
- Glioblastoma multiforme (1)
- Glucose Transporter 1 (1)
- HIFs (1)
- Hypoxia (1)
- Hypoxia Inducible Factors (1)
- Hypoxic tumor microenvironment (1)
- P53 (1)
- Scorpion (1)
- Theranostic (1)
- Treatment (1)
- Warburg Effect (1)
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Cd147 As A Potential Therapeutic Target In Glioblastoma Treatment, Beau Adams
Cd147 As A Potential Therapeutic Target In Glioblastoma Treatment, Beau Adams
All NMU Master's Theses
Glioblastoma (GBM) tumors are the most common and lethal form of cancer in the central nervous system (CNS). GBM tumors appear to contain a mixture of different cell types, which makes them difficult to treat. GBM cells exhibit altered morphology from normal cells on several different levels, which highlights different pathways to potentially target for therapeutic treatments. The human surface glycoprotein CD147, also known as basigin, is expressed at significantly higher levels in GBMs compared to non-neoplastic brain tissue. Furthermore, levels of CD147 expression correlate with brain tumor progression and show the highest expression in GBM. Here, we suppressed tumor …
Characterization Of Theranostic Peptides For Glioblastoma Multiforme, Aaron Mellesmoen
Characterization Of Theranostic Peptides For Glioblastoma Multiforme, Aaron Mellesmoen
All NMU Master's Theses
Glioblastoma multiforme (GBM) is a type of primary CNS tumor in which viable treatment options do not exist. Standard of care including tumor resection, chemotherapy, and radiation does little to extend the 5-year survival expectancy past 5.1%. Herein, two small-peptide molecules with inherent antitumor activity, blood-brain barrier permeability, and capability for tumor-specific drug deliverance and intraoperative visualization (termed theranostic) were of focus. Confocal microscopy was employed to characterize in vitro specificity of chlorotoxin, a 4 kDa scorpion venom peptide, and rBSG, the recombinant 25 kDa non-glycosylated extracellular domain of extracellular matrix metalloproteinase inducer (EMMPRIN; Basigin) isoform …
Hypoxia-Regulated Expression Of Glut-1 In Gbm Cell Lines, Marissa Kane
Hypoxia-Regulated Expression Of Glut-1 In Gbm Cell Lines, Marissa Kane
All NMU Master's Theses
Unlike normal cells, cancer cells can grow in low oxygen (hypoxic) environments. Changes in relative oxygen concentration can alter gene expression in tumors to allow for their selective growth. The result of such changes allows the tumor to adapt its cellular metabolism and promote tumor progression. Most notably, hypoxic conditions induce expression of the transcription factor hypoxia inducible factor 1 (HIF-1). HIF-1 is thought to directly affect glucose transporter 1 (GLUT1) expression levels in hypoxic conditions. This study sought to determine the relationship between HIF-1 and GLUT1 expression levels within normoxic and hypoxic environments utilizing an in-vitro GBM model. The …