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Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Uncovering New Roles For The Aryl Hydrocarbon Receptor (Ahr) In Breast Cancer, Justin Kirk Tomblin
Uncovering New Roles For The Aryl Hydrocarbon Receptor (Ahr) In Breast Cancer, Justin Kirk Tomblin
Theses, Dissertations and Capstones
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is responsive to many exogenous and endogenous ligands. AHR is of particular interest in cancer, and has been shown to play roles in tumor progression. As such, it has received growing attention as a possible chemotherapeutic target. Obesity increases the risk of breast cancer, complicates treatment of breast cancer, and stimulates the growth of larger, more aggressive mammary tumors. Many breast tumors in obese women are estrogen receptor (ER)-positive and, while targeting hormone receptors like ER is beneficial, many obese women see a recurrence of their cancer after standard …
Adult Neural Stem Cell Differentiation And Signaling Is Disrupted By Low-Level Silver Nanoparticle Exposure In Vitro, Robert Jefferson Cooper
Adult Neural Stem Cell Differentiation And Signaling Is Disrupted By Low-Level Silver Nanoparticle Exposure In Vitro, Robert Jefferson Cooper
Theses, Dissertations and Capstones
Silver nanoparticles (AgNP) are an emerging environmental contaminant with unique chemical and physical properties. They are utilized in products like medical dressings and children’s toys for their antimicrobial action. Though AgNP’s bioaccumulative nature and high-level toxicity are established, low-level effects from chronic exposure to AgNP-containing products and environmental AgNP remain unclear. This study uses adult neural stem cells, a model for neural cell function and neurodevelopment, to assess changes in cell differentiation and behavior following low-level AgNP exposure. In vitro, low-level AgNP produced dose- and timedependent formation of co-localized f-actin inclusions and β-catenin puncta. Neurite extension and arborization were also …
3,5-Dichloroaniline: Biotransformation And Mechanistic Aspects Of Nephrotoxicity In Vitro, Christopher Robert Racine
3,5-Dichloroaniline: Biotransformation And Mechanistic Aspects Of Nephrotoxicity In Vitro, Christopher Robert Racine
Theses, Dissertations and Capstones
Chlorinated anilines have been used as important chemical intermediates in the production of a wide variety of pharmaceutical, industrial, and agricultural products. Exposure to chloroanilines can arise in both occupational and environmental settings and can lead to toxicity to multiple organs, including the kidney. Previous studies have established that of the mono- and dichlorinated anilines, 3,5-dichloroaniline (3,5-DCA) possesses the most nephrotoxic potential both in vitro and in vivo. However, little is known concerning the role of renal metabolism in nephrotoxicity. The studies presented in the following dissertation are the first to explore the toxicity, metabolism, and bioactivation of 3,5-DCA in …