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Apoptosis Of Dedifferentiated Hepatoma Cells Is Independent Of Nf-Jb Activation In Response To Lps, M. Ryan Reidy, Janette Ellis, Erin A. Schmitz, David M. Kraus, Gary A. Bulla
Apoptosis Of Dedifferentiated Hepatoma Cells Is Independent Of Nf-Jb Activation In Response To Lps, M. Ryan Reidy, Janette Ellis, Erin A. Schmitz, David M. Kraus, Gary A. Bulla
Faculty Research & Creative Activity
Dedifferentiated hepatoma cells, in contrast to most other cell types including hepatoma cells, undergo apoptosis when treated with lipopolysaccharide (LPS) plus the protein synthesis inhibitor cycloheximide (CHx). We recently reported that the dedifferentiated hepatoma cells also exhibit a strong and prolonged NF-jB induction phenotype upon exposure to LPS, suggesting that NF-jB signaling may play a pro-survival role, as reported in several other cell systems. To test the role of NF-jB in preventing LPS-mediated apoptosis, we examined the dedifferentiated cell line M38. Results show that antioxidants strongly inhibited LPS + CHx-mediated cell death in the M38 cells, yet only modestly inhibited …
Apoptosis Of Dedifferentiated Hepatoma Cells Is Independent Of Nf-Jb Activation In Response To Lps, M. Reidy, Janette Ellis, Erin Schmitz, David Kraus, Gary Bulla
Apoptosis Of Dedifferentiated Hepatoma Cells Is Independent Of Nf-Jb Activation In Response To Lps, M. Reidy, Janette Ellis, Erin Schmitz, David Kraus, Gary Bulla
Faculty Research & Creative Activity
Dedifferentiated hepatoma cells, in contrast to most other cell types including hepatoma cells, undergo apoptosis when treated with lipopolysaccharide (LPS) plus the protein synthesis inhibitor cycloheximide (CHx). We recently reported that the dedifferentiated hepatoma cells also exhibit a strong and prolonged NF-jB induction phenotype upon exposure to LPS, suggesting that NF-jB signaling may play a pro-survival role, as reported in several other cell systems. To test the role of NF-jB in preventing LPS-mediated apoptosis, we examined the dedifferentiated cell line M38. Results show that antioxidants strongly inhibited LPS + CHx-mediated cell death in the M38 cells, yet only modestly inhibited …