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Full-Text Articles in Life Sciences
Exploring The Effects Of Protein Kinase C-Alpha Gene Knockout On The Proliferation Of Human Embryonic Kidney Cells, Emma J. Kuntz
Exploring The Effects Of Protein Kinase C-Alpha Gene Knockout On The Proliferation Of Human Embryonic Kidney Cells, Emma J. Kuntz
Honors Program Projects
Signaling molecules have important roles in many cellular functions, but because these pathways are incredibly complex, the exact mechanisms often remain unknown. One signaling molecule, protein kinase C alpha (PKCa), is involved in cell proliferation and is expressed at high levels in many cancers. Interestingly, its activity as a tumor promoter or tumor suppressor varies depending on the cell type for reasons not yet fully understood. This study aimed to investigate the role of PKCa in cell proliferation in order to better understand its function as a signaling molecule. To asses this, a knockout line was generated using CRISPR-Cas9 and …