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Integrins Have Cell-Type-Specific Roles In The Development Of Motor Neuron Connectivity, Devyn Oliver, Emily Norman, Heather Bates, Rachel Avard, Monika Rettler, Claire Y. Bénard, Michael M. Francis, Michele L. Lemons
Integrins Have Cell-Type-Specific Roles In The Development Of Motor Neuron Connectivity, Devyn Oliver, Emily Norman, Heather Bates, Rachel Avard, Monika Rettler, Claire Y. Bénard, Michael M. Francis, Michele L. Lemons
Biological and Physical Sciences Department Faculty Works
Formation of the nervous system requires a complex series of events including proper extension and guidance of neuronal axons and dendrites. Here we investigate the requirement for integrins, a class of transmembrane cell adhesion receptors, in regulating these processes across classes of C. elegans motor neurons. We show α integrin/ina-1 is expressed by both GABAergic and cholinergic motor neurons. Despite this, our analysis of hypomorphic ina-1(gm144) mutants indicates preferential involvement of α integrin/ina-1 in GABAergic commissural development, without obvious involvement in cholinergic commissural development. The defects in GABAergic commissures of ina-1(gm144) mutants included both premature termination and guidance …