Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Investigation Of Murine Spleen As A Niche For Hematopoiesis., Jonathan Tan, Helen O'Neill
Investigation Of Murine Spleen As A Niche For Hematopoiesis., Jonathan Tan, Helen O'Neill
Helen O'Neill
Background Spleen as a lymphoid tissue is specialized for monitoring blood and mounting immunity against blood-borne antigens. Antigen-presenting cells present in spleen commonly develop from bone marrow-derived precursors that enter blood circulation. However, a distinct splenic myeloid antigen-presenting cell subset described in this laboratory, namely “dendritic-like cells” (L-DC), has been hypothesized not to share a bone marrow origin. Methods In this study, the presence of endogenous hematopoietic progenitors in spleen was investigated by transplanting intact spleen into allotype-distinct recipients and monitoring development of progeny cells in grafted tissues. Results Successful engraftment of donor spleens was achieved for up to 4 …