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Full-Text Articles in Life Sciences
Investigating The Role Of Protein Kinase A In The Control Of Focal Adhesion And Traction Force Dynamics, Amanda Senatore
Investigating The Role Of Protein Kinase A In The Control Of Focal Adhesion And Traction Force Dynamics, Amanda Senatore
Graduate College Dissertations and Theses
Cellular adhesion to the extracellular environment is a critical component of physiological processes and its dysregulation drives pathological processes such as cancer metastasis. The input cells derive from their interaction with the extracellular matrix (ECM) is largely mediated through specialized organelles known as focal adhesions (FAs). FAs tether extracellular matrix-bound integrins to the contractile actin cytoskeleton and serve as attachment points which allow the cell to exert force on the extracellular environment via acto-myosin contractility. In addition to this structural role, FAs function as dynamic signaling hubs that respond to changes in force. Reversible phosphorylation plays a major role in …
The Maintenance Of Genomic Stability: Impacts Of The Loss Of Kif18a, Leslie Anne Sepaniac
The Maintenance Of Genomic Stability: Impacts Of The Loss Of Kif18a, Leslie Anne Sepaniac
Graduate College Dissertations and Theses
Regulated and repeated cell division is necessary for the development, growth, and reproduction of multicellular organisms. A central purpose of mitosis is to faithfully pass hereditary information from one cell onto two genetically identical daughter cells, thus maintaining genomic stability. Cells employ several mechanisms for maintaining genomic stability, including well-characterized cell cycle checkpoints. However, chromosome segregation errors can occur in spite of these regulatory mechanisms. Such errors can result in an improper number of chromosomes being distributed to daughter cells – termed aneuploidy – or improper localization of chromosomes into separate satellite nuclei – termed micronuclei. What, if any, additional …
The Role Of Peroxiredoxin 4 And Er Redox Stress In Idiopathic Pulmonary Fibrosis, Evan Elko
The Role Of Peroxiredoxin 4 And Er Redox Stress In Idiopathic Pulmonary Fibrosis, Evan Elko
Graduate College Dissertations and Theses
Idiopathic Pulmonary Fibrosis (IPF) is a disease that is characterized by excessive scar formation in the lung. IPF is a disease associated with aging and is believed to be the manifestation of repeated micro-injuries and lack of adequate repair over time. Notably increases in endoplasmic reticulum (ER) stress of epithelial cells and excessive epithelial cell death have been identified as processes that drive the progression of fibrosis. Every year 34,000 people in the United States are diagnosed with Idiopathic Pulmonary Fibrosis (IPF). The average survival time for these patients is only 3-5 years after diagnosis. Two available drugs stabilize patients …