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Characterization Of The Function Of The Azospirillum Brasilense Che1 Chemotaxis Pathway In The Regulation Of Chemotaxis, Cell Length And Clumping, Amber Nicole Bible
Characterization Of The Function Of The Azospirillum Brasilense Che1 Chemotaxis Pathway In The Regulation Of Chemotaxis, Cell Length And Clumping, Amber Nicole Bible
Doctoral Dissertations
Azospirillum brasilense is a gram-negative alphaproteobacterium that lives in the soil where it colonizes the root surfaces of cereals and grasses. The genome of A. brasilense has recently been sequenced and shown to possess four different chemotaxis-like operons. This dissertation project focused on characterizing the Che1 chemotaxis-like signal transduction pathway, which was initially implicated in regulation of the chemotaxis behavior. Deletions of individual genes within the Che1 pathway did not exhibit a null chemotaxis phenotype, leading us to investigate the role of this pathway in the lifestyle of A. brasilense and the mechanism(s) by which it functions. We have used …
Novel Constitutively Active Point Mutations In The Nh2 Domain Of Cxcr2 Capture The Receptor In Different Activation States, Giljun Park
Doctoral Dissertations
Chemokines are structurally and functionally related 8-10 kDa proteins defined by four conserved cysteine residues. They consist of a superfamily of proinflammatory mediators that promote the recruitment of various kinds of leukocytes and other cell types through binding to their respective chemokine receptor, a member of the GPCR family. Abnormal control of this system results in various diseases including tumorigenesis and cancer metastasis. Deregulation can occur when constitutively active mutant (CAM) chemokine receptors are locked in the “on” position. This can lead to cellular transformation/tumorigenesis. A viral CAM receptor, ORF74, that can cause tumors in humans, also has homology to …