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Understanding The Meiotic Roles Of Sisters Unbound In Drosophila Melanogaster, Badri Krishnan
Understanding The Meiotic Roles Of Sisters Unbound In Drosophila Melanogaster, Badri Krishnan
Doctoral Dissertations
During meiosis, cohesin is required for sister chromatid cohesion and for formation of chromosome cores. Multiple processes including chromosome segregation, recombination and synaptonemal complex (SC) are dependent on cohesin. Cohesin complex consists of two SMC subunits- SMC1, SMC3 and two non-SMC subunits RAD21/REC8 in meiosis and SA. But in Drosophila, non-SMC subunits have not been shown to be required for cohesion. We have identified a gene sisters unbound, which along with previously identified ord and solo, form a group of three genes (sos) which do not have any sequence similarity to cohesins but performs functions …
Studies On The Mechanism Of Homolog Pairing In Drosophila Male Meiosis, Jui-He Tsai
Studies On The Mechanism Of Homolog Pairing In Drosophila Male Meiosis, Jui-He Tsai
Doctoral Dissertations
Drosophila male is an example of achiasmatic meiosis which lacks crossingover and chiasmata during meiosis. Previous studies showed that homologous pairing of both euchromatin and centromeres is lost during middle prophase I, however, homologs are still connected as they form bivalents. The X-Y pair utilizes a specific repeated sequence within the heterochromatic ribosomal DNA blocks as a pairing site. No pairing sites have yet been identified for the autosomes. To search for such sites, we utilized probes specifically targeting heterochromatin regions to assay pairing sequences and behavior in meiosis by fluorescence in situ hybridization (FISH). We found that the fourth …