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New Insights In The Tssk Family: Studies In The Activity And Function Of The Testis Specific Serine Kinases, Julian Sosnik
New Insights In The Tssk Family: Studies In The Activity And Function Of The Testis Specific Serine Kinases, Julian Sosnik
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The Testis Specific Serine Kinase (Tssk) family of proteins is a large group of kinases that present high level of conservation within paralogs, as well as within species. In addition, in all reported cases as well as in the analysis of expressed sequence tags available in databases, this family of proteins presents a very strict pattern of either testicular or male-gonadal expression. This high level of conservation prompted the postulate that these kinases ought to be important for either testicular function or fertilization. In this work we attempt a biochemical characterization of one family member (Tssk6) in the mouse. We …