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Cellular Mechanisms Underlying Myogenic Reactivity In Isolated Arterioles, Hui Zou
Cellular Mechanisms Underlying Myogenic Reactivity In Isolated Arterioles, Hui Zou
Theses and Dissertations in Biomedical Sciences
The myogenic reactivity provides one of the principal mechanisms for blood flow autoregulation. The aims of the performed studies described in this dissertation were to test the role of [Ca2+]i and MLC phosphorylation in arteriolar myogenic reactivity and further examine the source(s) of activator Ca2+ required to initiate and maintain myogenic vasoconstriction. In addition, the possible underlying mechanism of contractile protein expression was also addressed.
These studies used male Sprague Dawley rats of 200 ~ 350 grams body weight. Experiments were carried out using rat cremaster first order arterioles and mesenteric vessels. Gel electrophoresis and immunoblotting …