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Regulation Of The Retinoblastoma Tumor Suppressor By The Novel Ras Effector Nore1a., Thibaut François Barnoud
Regulation Of The Retinoblastoma Tumor Suppressor By The Novel Ras Effector Nore1a., Thibaut François Barnoud
Electronic Theses and Dissertations
Ras is the most frequently mutated oncogene in human cancers. It acts as a critical branch point in signal transduction, regulating numerous downstream effectors involved in cell growth and differentiation. While Ras can activate many growth promoting pathways, it can paradoxically regulate growth inhibitory pathways leading to apoptosis and cell cycle arrest. One of the ways Ras can inhibit the growth of cells is via a family of effectors called the RASSF proteins. RASSF5 (NORE1A) is a tumor suppressor that is frequently inactivated in human tumors by epigenetic mechanisms. NORE1A binds directly to Ras and promotes Ras-induced senescence. We have …