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The Loss Of Atrx Creates Susceptibility To Kras-Mediated Pancreatic Damage, Claire C. Young
The Loss Of Atrx Creates Susceptibility To Kras-Mediated Pancreatic Damage, Claire C. Young
Electronic Thesis and Dissertation Repository
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a five-year survival rate of 8%. Oncogenic KRAS mutation is found in greater than 95% of PDAC cases, but additional mutations or injury are required for disease initiation and progression. Chromatin remodeling protein ATRX has been previously implicated in DNA repair, replication and maintaining genomic stability. I hypothesized that loss of ATRX could increase the susceptibility of pancreatic tissue to pancreatic injury or KRAS-mediated damage. In this study, combination of inducible ATRX loss in adult mice with recurrent pancreatic injury or oncogenic KRAS activation resulted in increased pancreatic damage, including fibrosis, …