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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
An Analysis Of The Use Of Dogs In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls
An Analysis Of The Use Of Dogs In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls
Laboratory Experiments Collection
Dogs remain the main non-rodent species in preclinical drug development. Despite the current dearth of new drug approvals and meagre pipelines, this continues, with little supportive evidence of its value or necessity. To estimate the evidential weight provided by canine data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive dataset of 2,366 drugs with both animal and human data, including tissue-level effects and Medical Dictionary for Regulatory Activities (MedDRA) Level 1–4 biomedical observations. The resulting LRs show that the absence of toxicity in dogs provides virtually no …
An Hsus Report: Industrial Farm Animal Production And Livestock Associated Mrsa (Methicillin Resistant Staphylococcus Aureus), The Humane Society Of The United States
An Hsus Report: Industrial Farm Animal Production And Livestock Associated Mrsa (Methicillin Resistant Staphylococcus Aureus), The Humane Society Of The United States
Impact of Animal Agriculture
Staphylococcus aureus is a leading cause of bacterial infection and is increasingly found to be resistant to antibiotic therapy. A newly described type of Methicillin Resistant Staphylococcus aureus carried by farm animals, Livestock Associated MRSA (LA-MRSA), is now causing infections in humans with and without direct livestock contact. A reduction in the non-therapeutic use of antibiotics in feed would likely reduce the capacity of industrial animal agriculture to continue to create, disseminate, and perpetuate a large reservoir of LA-MRSA on a global scale, but more fundamental changes in the way animals are raised for food may be necessary forestall a …
Environmental Impacts Of One Puppy Mill Among Many: A Case History, John A. Gill
Environmental Impacts Of One Puppy Mill Among Many: A Case History, John A. Gill
Puppy Mills Collection
In recent decades, the animal welfare aspects of irresponsibly-managed commercial dog-breeding businesses have attracted national attention, prompting legislative and regulatory actions. However, the environmental impacts of such businesses, also known as puppy mills, have received far less attention. Most puppy mills are secretive; therefore, it is hard to get documented information about their environmental impacts. Although the former Whispering Oaks Kennels near Parkersburg, W.Va., also kept secrets, reliable environmental information regarding its operation became available because in the summer of 2008, Wood County cited the facility for violating the State’s water pollution and solid waste statutes. This report is based …
Environmental Impacts Of Puppy Mills, The Humane Society Of The United States
Environmental Impacts Of Puppy Mills, The Humane Society Of The United States
PUPPY MILL REPORTS
A puppy mill is “a dog breeding operation in which the health of the dogs is disregarded in order to maintain a low overhead and maximize profits.” Avenson v. Zegart, 577 F. Supp. 958, Dist. Court, Minnesota (1984). State and federal inspection reports reveal that a common method employed to maximize profits includes irresponsible waste management practices that are harmful to the environment. Impacts may be caused by improper disposal of feces, urine and carcasses.
Associations Of Housing, Management, Milking Activity, And Standing And Lying Behavior Of Dairy Cows Milked In Automatic Systems, Justine A. Deming, Renée Bergeron, Kenneth E. Leslie, Trevor J. Devries
Associations Of Housing, Management, Milking Activity, And Standing And Lying Behavior Of Dairy Cows Milked In Automatic Systems, Justine A. Deming, Renée Bergeron, Kenneth E. Leslie, Trevor J. Devries
Farm Animal Husbandry Collection
The objective of this cross-sectional study was to describe the housing, feeding management, and characteristics (parity and stage of lactation) of cows on commercial automatic milking system (AMS) dairies and their associations with the standing and lying behavior patterns and milking activity (frequency and yield) of lactating dairy cows. Thirteen AMS herds were enrolled in the study, with an average herd size of 71 ± 30 (mean ± SD; range: 34 to 131) lactating cows. All of the herds used freestall barns, each set up for free cow traffic to the AMS. On-farm measurements were taken to determine stocking density …