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Protective Potential Of Mokko Lactone From Cheilocostus Speciosus (J. Koenig) C.D.Specht (Costaceae) Rhizomes Against Fulminant Hepatic Failure, Ahmed Altyar, Ikhlas Sindi, Dina El-Agamy, Wael Elsaed, Ahmed Shehata, Hossam Abdallah, Gamal Mohamed, Abdelsattar Omar, Sabrin Ibrahim
Protective Potential Of Mokko Lactone From Cheilocostus Speciosus (J. Koenig) C.D.Specht (Costaceae) Rhizomes Against Fulminant Hepatic Failure, Ahmed Altyar, Ikhlas Sindi, Dina El-Agamy, Wael Elsaed, Ahmed Shehata, Hossam Abdallah, Gamal Mohamed, Abdelsattar Omar, Sabrin Ibrahim
Turkish Journal of Botany
Cheilocostus speciosus (Syn: Costus speciosus) (Crepe or spiral ginger) is one of the species of the family Costaceae that is widely used in various traditional medicines for treating various ailments. Mokko lactone (ML) belongs to the guaianolide family of sesquiterpenes, which has been separated from C. speciosus. It showed noticeable antiinflammation and antioxidative capacities. The current study explored the ML hepatoprotective potential against FHF (fulminant hepatic failure) in mice. FHF was successfully established using intraperitoneal injection of ?-galactosamine (?-GalN, 700 mg/kg)/lipopolysaccharide (LPS, 10 µg/kg) in male Swiss-albino mice. The mice were pretreated with ML (20 or 40 mg/kg, orally) daily …