Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Drug delivery (2)
- Agriculture (1)
- Alzheimer's Disease (1)
- ApoE (1)
- Bioorthogonal (1)
-
- CNC (1)
- CNT (1)
- CRISPR-Cas9 (1)
- Cellular (1)
- Chromatin (1)
- Click chemistry (1)
- Commodities (1)
- Disassembly (1)
- Enzyme-responsive (1)
- Expanded genetic code (1)
- Fibrillar Nanoparticle (1)
- Food (1)
- Future (1)
- Gene editing (1)
- Gene regulation (1)
- Genetic engineering (1)
- Genome editing (1)
- Genome organization (1)
- He Jiankui (1)
- Insulators (1)
- MMP (1)
- Meat (1)
- Microglia (1)
- Nanomedicine (1)
- Neuroimmunology (1)
Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
Feeding The Future Meat Doesn’T Come Cheap, Lukas C. Southard
Feeding The Future Meat Doesn’T Come Cheap, Lukas C. Southard
Capstones
Cultured – or as it is referred to by companies innovating the technology clean – meat is expected to be the next innovation to change the way the world gets its animal protein. Meat from animal cells grown in a lab seems like science fiction but it is around the corner from hitting your supermarket shelves. The technology has been developed but how these companies intend on scaling up their production to meet retail demands remains a mystery. So far companies have relied on seed and early stage investment from venture capital companies and private sources to fund research. Predictions …
Eugenics In The 21st Century, Jessica Linn Chin
Eugenics In The 21st Century, Jessica Linn Chin
Dissertations, Theses, and Capstone Projects
Eugenics is the science of enhancing the human population through the management of breeding and hereditary traits. This thesis explores the history of eugenics and shows how eugenic practices continue in the 21st century with advancements in technology and positive eugenic goals that can result in adverse effects on the human body and society. When Sir Francis Galton coined the term eugenics in 1883, he intended to improve British society with the use of positive eugenics. Galton used positive eugenics to encourage people with good mental and physical qualities to produce more children. He avoided negative eugenics, which involved …
Developing A Dissociative Nanocontainer For Peptide Drug Delivery, Michael Patrick Kelly
Developing A Dissociative Nanocontainer For Peptide Drug Delivery, Michael Patrick Kelly
Dissertations, Theses, and Capstone Projects
The potency and specificity of bioactive peptides have propelled these agents to the forefront of pharmacological research. However, delivery of peptides to their molecular target in cells is a major obstacle to their widespread application. A Trojan Horse strategy of packaging a bioactive peptide within a modified protein cage to protect it during transport, and releasing it at the target site, is a promising delivery method. Recent work has demonstrated that the viral capsid of the P22 bacteriophage can be loaded with an arbitrary, genetically-encoded peptide, and externally decorated with a cell-penetrating peptide, such as HIV-Tat, to translocate across in …
Renal Specific Rnai Delivery By Fibrillar Nanoparticle Excipients, Sam Wong
Renal Specific Rnai Delivery By Fibrillar Nanoparticle Excipients, Sam Wong
Dissertations, Theses, and Capstone Projects
RNA interference (RNAi) is a powerful tool to manipulate the phenotype of an organism by silencing the expression of specific genes and is viewed as a highly promising platform for treating undruggable targets and disorders where small molecule drugs and antibodies would fail. However, development of RNAi based therapies has faced major barriers including cellular and tissue-specific uptake of the Small Interfering RNA (siRNA). Utilizing different nanoparticles as RNAi excipients, cellular uptake and gene silencing potency can be greatly improved. The research in Dr. McDevitt groups has fibrillar carbon nanotubes (CNT) as carriers for siRNA for gene silencing in vitro …
Design And Application Of Matrix Metalloproteinase-9-Responsive Peptide Nanostructures, Jiye Son
Design And Application Of Matrix Metalloproteinase-9-Responsive Peptide Nanostructures, Jiye Son
Dissertations, Theses, and Capstone Projects
Matrix metalloproteinase (MMP)-responsive materials have been investigated since the late 1990’s as scaffolds for tissue engineering and since then, have evolved into sophisticated nanomaterials for cancer-targeting therapy. In this thesis titled, “Design and Application of Matrix Metalloproteinase-9-Responsive Peptide Nanostructures,” we aim to answer the following key questions: can MMP-responsive nanomaterials improve the efficacy of anti-cancer treatments? How can we achieve specificity towards MMPs using nanomaterials? Finally, what are the advantages in using peptides as building blocks to create MMP-responsive nanostructures? Each chapter in the thesis will address one or more of the key questions and draw conclusions at the end.
Identification And Characterization Of Barrier Insulator Activity In The T-Cell Receptor Alpha Locus Control Region, Gayathri Devi Raghupathy
Identification And Characterization Of Barrier Insulator Activity In The T-Cell Receptor Alpha Locus Control Region, Gayathri Devi Raghupathy
Dissertations, Theses, and Capstone Projects
Genes of different spatiotemporal expression profiles are often juxtaposed in the genome. This organization raises risks of cross-regulatory influences from neighboring genes; for instance heterochromatin can spread over euchromatin or long-range acting enhancers can inappropriately activate genes. Gene regulatory elements such as Locus Control Regions (LCR) and Insulators prevent such cross-communications and allow for normal gene expression patterns. In transgenic systems, LCRs limit influences from surrounding chromatin by providing site-of-integration independent and specific spatiotemporal expression upon a linked transgene. The field’s understanding of the ability of an LCR to overcome chromatin influences and allow site-of-integration independent expression is minimal. Interestingly, …
Pretargeted Radioimmunotherapy Utilizing The Inverse Electron Demand Diels-Alder Reaction, Rosemery Membreno
Pretargeted Radioimmunotherapy Utilizing The Inverse Electron Demand Diels-Alder Reaction, Rosemery Membreno
Dissertations, Theses, and Capstone Projects
Radioimmunotherapy capitalizes on the specificity and affinity of antibodies for their antigens to localize radioactivity at the tumor site. One limitation in using antibodies is their long circulation time, which can take days to weeks to fully clear from blood circulation. When a radioisotope is directly conjugated to this immunoglobulin vector, the red marrow and other healthy organs are receiving a constant radiation dose while it is in blood circulation. This not only harms healthy organs, but limits the dose of radioactivity that can be administered thus prolonging treatment. A promising alternative to limit the radiation dose to non-tumor tissue …
Mechanisms Of Microglia Mediated Apolipoprotien E Neurotoxicity, Pardeep Singh
Mechanisms Of Microglia Mediated Apolipoprotien E Neurotoxicity, Pardeep Singh
Dissertations and Theses
No abstract provided.