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Full-Text Articles in Life Sciences

The Complexity Of Molecular Interactions And Bindings Between Cyclic Peptide And Inhibit Polymerase A And B1 (Pac-Pb1n) H1n1, Arli A. Parikesit, Harry Noviardi Hn, Djati Kerami Dk, Usman Sumo Friend Tambunan Usft Nov 2014

The Complexity Of Molecular Interactions And Bindings Between Cyclic Peptide And Inhibit Polymerase A And B1 (Pac-Pb1n) H1n1, Arli A. Parikesit, Harry Noviardi Hn, Djati Kerami Dk, Usman Sumo Friend Tambunan Usft

Arli A Parikesit

The influenza/H1N1 virus has caused hazard in the public health of many countries. Hence, existing influenza drugs could not cope with H1N1 infection due to the high mutation rate of the virus. In this respect, new method to block the virus was devised. The polymerase pac-pb1n enzyme is responsible for the replication of H1N1 virus. Thus, novel inhibitors were developed to ward off the functionality of the enzyme. In this research, cyclic peptides has been chosen to inhibit PAc-PB1n due to its proven stability in reaching the drug target. Thus, computational method for elucidating the molecular interaction between cyclic peptides …


Atomic, Crystalline And Powder Characteristics Of Treated Zirconia And Silica Powders, Mahendra Kumar Trivedi Nov 2014

Atomic, Crystalline And Powder Characteristics Of Treated Zirconia And Silica Powders, Mahendra Kumar Trivedi

Mahendra Kumar Trivedi

Zirconium oxide and silicon dioxide powders are selected and subjected to a non-contact Biofield energy known to be transmitted by Mahendra Kumar Trivedi. Particle sizes d50 and d99 showed up to 71.5 percent decrease indicating that the energy had caused deformation and fracture as if the powders have been subjected to high energy milling. This is also supported by increase in specific surface area up to 19.48 percent. In the present investigation Zirconium oxide and silicon dioxide powders are exposed to Bio-field. Both the exposed and unexposed powders are later characterized by various techniques. The treated powders when characterized by …


Comparative Studies Of Oleaginous Fungal Strains (Mucor Circinelloides And Trichoderma Reesei) For Effective Wastewater Treatment And Bio-Oil Production, Anshuman Bhanja, Gauri P. Minde, Sandip S. Magdum, Kalyanraman V. Nov 2014

Comparative Studies Of Oleaginous Fungal Strains (Mucor Circinelloides And Trichoderma Reesei) For Effective Wastewater Treatment And Bio-Oil Production, Anshuman Bhanja, Gauri P. Minde, Sandip S. Magdum, Kalyanraman V.

Sandip S. Magdum

Biological wastewater treatment typically requires the use of bacteria for degradation of carbonaceous and nitrogenous compounds present in wastewater. The high lipid containing biomass can be used to extract oil and the contents can be termed as bio-oil (or biodiesel or myco-diesel after transesterification). The separate experiments were conducted on actual wastewater samples with 5% v/v inoculum of Mucor circinelloides MTCC1297 and Trichoderma reesei NCIM992 strains. The observed reductions in chemical oxygen demand (COD) were 88.72% and 86.75% in 96 hrs and the observed substrate based biomass yields were 0.21 mg VSS/mg COD and 0.22 mg VSS/mg COD for M. …


Experimental Demonstration Of Bindingless Signal Delivery In Human Cells Via Microfluidics, Fang-Tzu Chuang Jul 2014

Experimental Demonstration Of Bindingless Signal Delivery In Human Cells Via Microfluidics, Fang-Tzu Chuang

Fang-Tzu Chuang

The cellular signal transduction is commonly believed to rely on the direct “contact” or “binding” of the participating molecule reaction that depends positively on the corresponding molecule concentrations. In living systems, however, it is somewhat difficult to precisely match the corresponding rapid “binding,” depending on the probability of molecular collision, existing in the cellular receptor-ligand interactions. Thus, a question arises that if there is another mechanism (i.e., bindingless) that could promote this signal communication. According to this hypothesis, we report a cellular model based on the examination of intracellular calcium concentration to explore whether the unidentified signal delivery in cells …


Biokimia Dan Teknologi Farmasi: Desain Obat Dan Vaksin Dengan Pendekatan Biomedis Molekular, Usman Sumo Friend Tambunan Usft, Arli A. Parikesit Aap Jun 2014

Biokimia Dan Teknologi Farmasi: Desain Obat Dan Vaksin Dengan Pendekatan Biomedis Molekular, Usman Sumo Friend Tambunan Usft, Arli A. Parikesit Aap

Arli A Parikesit

No abstract provided.


Modeled Impacts Of Cover Crops And Vegetative Barriers On Corn Stover Availability And Soil Quality, Ian J. Bonner, David J. Muth Jr., Joshua B. Koch, Douglas L. Karlen Jun 2014

Modeled Impacts Of Cover Crops And Vegetative Barriers On Corn Stover Availability And Soil Quality, Ian J. Bonner, David J. Muth Jr., Joshua B. Koch, Douglas L. Karlen

David J. Muth

Environmentally benign, economically viable, and socially acceptable agronomic strategies are needed to launch a sustainable lignocellulosic biofuel industry. Our objective was to demonstrate a landscape planning process that can ensure adequate supplies of corn (Zea mays L.) stover feedstock while protecting and improving soil quality. The Landscape Environmental Assessment Framework (LEAF) was used to develop land use strategies that were then scaled up for five U.S. Corn Belt states (Nebraska, Iowa, Illinois, Indiana, and Minnesota) to illustrate the impact that could be achieved. Our results show an annual sustainable stover supply of 194 million Mg without exceeding soil erosion T …


Sensitivity Analysis And Parameter Identification For A Nonlinear Time-Delay System In Microbial Fed-Batch Process, Chongyang Liu Jan 2014

Sensitivity Analysis And Parameter Identification For A Nonlinear Time-Delay System In Microbial Fed-Batch Process, Chongyang Liu

Chongyang Liu

Developing suitable dynamic models of bioprocess is a difficult issue in bioscience. In this paper, considering the microbial metabolism mechanism, i.e., the production of new biomass is delayed by the amount of time it takes to metabolize the nutrients, in glycerol bioconversion to 1,3-propanediol, we propose a nonlinear time-delay system to formulate the fed-batch fermentation process. Some important properties are also discussed. Then, in view of the effect of time-delay and the high number of kinetic parameters in the system, the parametric sensitivity analysis is used to determine the key parameters. Finally, a parameter identification model is presented and a …


Inducing A Dielectric Barrier Discharge Plasma Within A Package, Vladimir Milosavljevic Jan 2014

Inducing A Dielectric Barrier Discharge Plasma Within A Package, Vladimir Milosavljevic

Vladimir Milosavljevic

Cold atmospheric plasma offers significant potential as a nonthermal decontamination tool for food and medical applications. We present results of a dielectric barrier discharge (DBD) plasma induced in a gas confined by a polymer package. The resultant discharge and contained afterglow are found to have a strong antimicrobial effect.


Inducing A Dielectric Barrier Discharge Plasma Within A Package, Vladimir Milosavljevic Jan 2014

Inducing A Dielectric Barrier Discharge Plasma Within A Package, Vladimir Milosavljevic

Vladimir Milosavljevic

Cold atmospheric plasma offers significant potential as a nonthermal decontamination tool for food and medical applications. We present results of a dielectric barrier discharge (DBD) plasma induced in a gas confined by a polymer package. The resultant discharge and contained afterglow are found to have a strong antimicrobial effect.


Fungal Solid-State Fermentation And Various Methods Of Enhancement In Cellulase Production, Li Wan Yoon, Teck Nam Ang Dr., Gek Cheng Ngoh Dr, Adeline Seak May Chua Dr Jan 2014

Fungal Solid-State Fermentation And Various Methods Of Enhancement In Cellulase Production, Li Wan Yoon, Teck Nam Ang Dr., Gek Cheng Ngoh Dr, Adeline Seak May Chua Dr

Teck Nam Ang Dr.

Cellulase serves vast applications in the industries of biofuel, pulp and paper, detergent and textile. With the presence of its three components i.e. endoglucanase, exoglucanase and β-glucosidase, the enzyme can effectively depolymerize the cellulose chains in lignocellulosic substrate to produce smaller sugar units that consists of cellobiase and glucose. Fungi are the most suitable cellase producers attributing to its ability to produce a complete cellulase system. Solid state fermentation (SSF) by fungi is a preferable production route for cellulase as it imposes lower cost and enables the production of cellulase with higher titre. This article gives an overview on the …