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Topical Administration Of Lacritin Peptide For The Treatment Of Canine Keratoconjunctivitis Sicca, Eliza A. Gaylord
Topical Administration Of Lacritin Peptide For The Treatment Of Canine Keratoconjunctivitis Sicca, Eliza A. Gaylord
Senior Honors Projects, 2010-2019
Keratoconjunctivitis sicca (KCS), also known as dry-eye disease, causes a deficiency of tears in both humans and canines. Due to the lack of effective therapeutics for the treatment of dry-eye disease, there is a market potential for a novel secretion enhancing factor. Lacritin, a naturally occurring tear glycoprotein, increases basal tearing in rabbits when topically applied to the ocular surface and shows potential as a dry-eye therapeutic. This study aims to characterize Lacritin as a biomarker of dry-eye disease in canines with KCS. A total of 46 canine tear samples, 24 normal and 22 diagnosed with KCS, were obtained through …