Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Development Of Quantitative Tools For The Characterization And Analysis Of The Blood Brain Barrier In Normal And Mps Iiib Mice, Sara M. Rigney
Development Of Quantitative Tools For The Characterization And Analysis Of The Blood Brain Barrier In Normal And Mps Iiib Mice, Sara M. Rigney
Dissertations, Masters Theses, Capstones, and Culminating Projects
The Blood Brain Barrier (BBB) functions to control homeostasis within the central nervous system (CNS) via strict control over the passage of molecules into and out of the brain. The goal of this barrier is to protect the CNS from harmful external factors while allowing entry of essential nutrients and removal of metabolic byproducts. This restrictive nature of the BBB is due to the protein network at the borders of adjoining cerebral endothelial cells known as the tight junctions (TJs) and the relationship of other supporting cells and proteins such as astrocytes, pericytes, microglia, and the basement membrane and extracellular …