Life Sciences Commons^™

Structural And Tissue-Level Adaptations Of Lumbar Intervertebral Discs In Humans With Inducible Low Back Pain Symptoms, Christian Isaiah Weber

McKelvey School of Engineering Theses & Dissertations

Low back pain (LBP) is a devastating musculoskeletal ailment that impacts majority of the global population. Up to 95% of cases are considered nonspecific where the origin is unclear. Although there is a diagnosis with these cases, there lacks specificity that would help individuals with treatment and pain management. Imaging techniques such as magnetic resonance imaging (MRI) are primarily utilized in the diagnosis of LBP as it illuminates internal structures of the spine. One important structure clearly identified with MRI is the intervertebral disc (IVD) that is susceptible to injury and disease. Further, diagnostic imaging is performed lying down where …

Discovering Motor Phenotypes In Autism Spectrum Disorder: A Cross-Syndrome Approach, Daniel Edwin Lidstone

UNLV Theses, Dissertations, Professional Papers, and Capstones

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with a behavioral phenotype characterized by persistent deficits in social communication and social interaction accompanied by restricted, repetitive patterns of behaviors, interests, or activities. Currently in the US, approximately 2.5% of children have a diagnosis of ASD. The etiology of ASD is complex, however the disorder does have a strong genetic basis. Specific genetic mutations can lead to neuroanatomical and neurophysiological changes during development resulting in a behavioral phenotype that falls along the ASD spectrum and may result in a diagnosis of ASD. The severity of ASD-specific behaviors falls on a continuum …

Wheelchair Propulsion For Everyday Manual Wheelchair Users: Repetition Training And Machine Learning-Based Monitoring, Pin-Wei Chen

Arts & Sciences Electronic Theses and Dissertations

Upper limb pain and injuries are prevalent among manual wheelchair users and can restrict their participation and daily activities. Due to the high repetition and force in wheelchair propulsion, chronic wheelchair propulsion has been linked to the risk of upper limb pain and injury. Prevention of upper limb pain and injury is a high priority in wheelchair-related research. Decades of research in wheelchair propulsion biomechanics have led to clinical practice guidelines (CPG). Unfortunately, a decade after the publication of the CPG, CPG-recommended propulsion is still uncommon. Hence, for the first aim, a randomized controlled trial pilot study with two groups …

Sexual Dimorphism And The Shape Of The Proximal Tibia In A Radiographic Sample, Emily Eiseman

Theses and Dissertations

SEXUAL DIMORPHISM AND THE SHAPE OF THE PROXIMAL TIBIA IN A RADIOGRAPHIC SAMPLE

This study investigates the use of radiographs to determine sexual dimorphism in the shape of the tibia. The goal of the research was to identify a small set of markers that would allow researchers to efficiently and accurately determine a person’s sex from a radiograph of the proximal tibia.

The sample consisted of radiographs including 75 females and 46 males ranging in age from 21 to 81. Measurements were taken on 27 points around the area of the knee including the tibia, patella, and femur. The measurements …

Assessing The Repeatability Of Clinical Tests In People With And Without Flexion-Induced Neck Pain, Ashton Human

Graduate Theses and Dissertations

The accessibility of mobile technology has improved productivity but can contribute to musculoskeletal disorders due to the posture associated with using such devices. Neck flexion, a posture assumed by smartphone users, has been shown as a risk factor for the development of clinical neck pain if sustained for prolonged periods. Determining the individuals who are naturally more predisposed to develop flexion-induced neck pain can aid in the prevention and treatment of musculoskeletal disorders. The purpose of this thesis is to assess the repeatability of clinical tests between trials over the course of two days in young adults who do and …

Serum Myostatin And Igf-1 As Biomarkers Of Sarcopenia: A Proof-Of-Concept Design, Ashley Binns

Graduate Theses and Dissertations

The population comprising older adults is growing exponentially, as are healthcare related costs. Nearly $20 billion is annually expensed by older adults for health-related issues affiliated with age-related decline in skeletal muscle mass. Yet, diagnostic criteria are not readily utilized in clinical practice. PURPOSE: Therefore, the purpose of this study was to provide evidence for use of blood biomarkers (myostatin, IGF-1) to predict appendicular skeletal muscle mass (ASM) among middle-aged and older adults. METHODS: A cross-sectional study was conducted among 106 individuals (n = 68 females; n = 38 males) aged ≥ 40 years of age (60.1 ± 11.1 y) …

Characterizing The Material Properties Of Abdominal Organs, Blake Allen Johnson

Theses and Dissertations

Understanding the behavior of abdominal organs under load will greatly improve several fields involving injury biomechanics. In order to determine the behavior of abdominal organs under load and be able to predict the response, the mechanical properties need to be properly characterized. The characterization of these properties will provide researchers the ability to create finite element models that will provide a better understanding of the mechanism of injury resulting from traumatic events.

Finite element models of today, that simulate traumatic injuries, lack properly characterized material properties. The current body of literature contains a large range of material property values which …

Ulnar Collateral Ligament Reconstruction With Traditional Docking Compared To Novel Surgical Techniques, Kayley D. Guy, Brendon P. Mcdermott, Kaitlin Gallagher, Tyrone Washington

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Ulnar Collateral Ligament Reconstruction (UCLR) is a surgical procedure on one of the main ligaments that provides normal stability for the elbow joint against excessive valgus stress. Damage to this ligament is common in athletes performing overhead throwing activities, primarily baseball players, due to excessive valgus stress during the throwing motion. The most common form of treatment for this type of injury is reconstructive surgery of the ligament, especially if athletes wish to return to sport participation. This type of surgery is extremely invasive and requires extensive post-operative rehabilitation in order to facilitate return to play. To date, many …

Does An Acute Achilles Tendon Rupture Become A Patient's Achilles Heel In The Long-Term?, Michaela Cm Khan

Electronic Thesis and Dissertation Repository

It is unknown if deficits in the involved limb following acute Achilles tendon rupture (AATR) persist in the long-term, or differ between patients treated operatively or non-operatively. This study investigated 43 patients 15±1 years post-AATR from a previous randomized controlled trial (RCT) that compared operative and non-operative treatment. Structural characteristics in the Achilles tendon and surrounding musculature were assessed using magnetic resonance imaging. We also performed physical examinations and evaluated performance-based and patient-reported outcomes. Overall, there were substantial differences between the involved and uninvolved limbs in most outcomes. Some outcomes improved over time from the initial RCT to the final …

Strains In Regions Of The Brain Modelled From Female Youth Soccer Players Performing Purposeful Headers In Season, Wayne Allison

Electronic Thesis and Dissertation Repository

Soccer is the world's most popular sport, and intentional heading of the ball is exclusive to it. Head impacts in youth players are riskier than adults as their brains are developing. Finite element models can quantify parameters, like strains within regions of the brain, that are otherwise difficult to assess. The purpose of this stay was to examine the relationship between head kinematics collected by wireless head impact sensors and brain strains in regions of interest related to concussion. As well, we assessed head impact strains in regions of interest related to concussion for headers from various game scenarios. In …

Development And Validation Of Wireless Sensors For Applications To Human Head Angular And Mechanical Motions, Karthick Natesan

USF Tampa Graduate Theses and Dissertations

In this project, we programmed a 9 degree of freedom Razor sensor, which incorporates an accelerometer and gyroscope to measure the head linear and angular motions produced by activities of daily living (ADL). The majority of studies concentrate on linear accelerations, so the purpose of this study is to determine the importance of both linear and angular components of acceleration in everyday activities and find interlinked relation between them. The sensor was validated using another calibrated and validated system. The general size and wireless nature make this sensor very suitable for use with human subjects. After obtaining informed consent, we …

Tracking Center Of Mass With Limited Inertial Measurement Units, Connor Nathaniel Morrow

Dissertations and Theses

Wearable motion tracking systems pose an opportunity to study and correct human balance and posture during movement. Currently, these observations are either being conducted in laboratories with the use of camera systems and markers placed on the body, or through the use of suits containing large numbers (15-20) of inertial measurement units. However, to aid with rehabilitation of individuals with impaired balance, there needs to be an option to collect these observations outside of clinics and without incurring much cost from the user. I have focused on three inertial measurement units, one placed on each shank and one placed on …

Development And Application Of New Methods For Magnetic Resonance Elastography Of The Brain, Charlotte Anne Guertler

McKelvey School of Engineering Theses & Dissertations

Accurate mechanical properties of the intact, living brain are essential for modeling traumatic brain injury (TBI). However, the properties of brain tissue in vivo have traditionally been measured in ex vivo samples. Magnetic resonance elastography (MRE) can be used to measure motion and estimate material properties of soft tissues in vivo, but MRE typically assumes tissue isotropy and homogeneity. The objective of this thesis is to improve MRE of soft tissue, like the brain, by developing and evaluating methods for in vivo estimation of heterogeneous, anisotropic properties. This was achieved through pursuit of the following aims: (1) quantifying the differences …

The Effects Of Anterior Cruciate Ligament Thickness, Knee Joint Laxity, Activity Level, Neuromuscular Imbalances And Lower Extremity Muscular Activation Patterns On Anterior Cruciate Ligament Loading, Zachary A. Sievert

Human Movement Studies & Special Education Theses & Dissertations

There are numerous known mechanisms of anterior cruciate ligament (ACL) injury risk that span from knee joint laxity to landing mechanics. However, the relationship of these mechanisms to ACL loading during landing is unclear. In addition to landing mechanics, anthropological aspects such as ACL diameter, which can now be obtained via ultrasound, may also be an important mechanism for ACL loading. However, the relationship between ACL diameter to ACL loading and landing mechanics remains unknown. This study was conducted with three primary purposes. The first purpose of this study was to examine the inter and intra-rater reliability of using ultrasound …

The Influence Of Strength In Load-Velocity Relationships In The Back Squat, Thaddeus Light

Electronic Theses and Dissertations

Load-velocity relationships may vary between people of different strength levels and across different loads. The purpose of this dissertation was to investigate how external loads influence the velocity characteristics of the back squat exercise, and the influence of strength on these variables. Healthy male students with a history of resistance training completed repetitions at specified intensities of their estimated one-repetition maximum (1RM) until they reached 1RM. Back squat 3D motion analysis was captured using four Vicon T010 cameras (Vicon Motion Systems Ltd.; Oxford, UK) and Vicon Nexus 1.8.5 software. Data were transported into R custom coding statistical analysis software (version …

Barbell Trajectory And Kinematics During Two International Weightlifting Championships, Aaron J. Cunanan

Electronic Theses and Dissertations

Several methods have been used in the scientific literature to study the weightlifting pull. Broadly, these methods are used to measure kinematic or kinetic variables exhibited by the lifter, the barbell, or the lifter-barbell system. However, there is an apparent disconnect between weightlifting research and coaching practice that may reduce the perceived benefits of technique analysis among coaches and present some challenges for coaches who seek to incorporate technique analysis into their coaching practice. Differences and trends in the technique of competitive weightlifting performances are apparent from the available literature. However, there are also gaps in the literature due to …

Multi-Tap Extended Kalman Filter For A Periodic Waveform With Uncertain Frequency And Waveform Shape, And Data Dropouts, Justin Saboury

Theses and Dissertations

Gait analysis presents the challenge of detecting a periodic waveform in the presence of time varying frequency, amplitude, DC offset, and waveform shape, with acquisition gaps from partial occlusions. The combination of all of these components presents a formidable challenge. The Extended Kalman Filter for this system model has six states, which makes it weakly identifiable within the standard Extended Kalman Filter network. In this work, a novel robust Extended Kalman Filter-based approach is presented and evaluated for clinical use in gait analysis. The novel aspect of the proposed method is that at each sample, the present and several past …

Quantitative Analysis Of The Kinematics Of The Foot During Gait With Respect To Barefoot Running Shoes Using A Multi-Segment Foot Model, Lisa Y. Oikawa

Electronic Thesis and Dissertation Repository

Kinematics of the foot during static and dynamic tasks are technically challenging to accurately measure, making it difficult to evaluate their contribution to running-related injuries. Motion capture can detect changes in running mechanics, such as with differing footwear. Habitual barefoot runners and/habitual minimalist shoe runners underwent a biomechanical evaluation of their foot movement during running using reflective markers and optical motion capture. A five-segment foot model was used to compare motions between the different parts of the foot while running barefoot and wearing Vibram Five Fingers™ (VFF) barefoot mimicking shoes. Supination/pronation in the forefoot was larger but not significant between …

Clinging In Plethodontid Salamanders, Mary Kathleen O'Donnell

USF Tampa Graduate Theses and Dissertations

The ability to cling to and climb on inclined, vertical, and inverted surfaces gives animals access to additional shelter and food and may provide refuge from unsuitable temperature and moisture conditions or escape from ground-dwelling predators. Salamanders have been shown to cling to surfaces and engage in climbing behavior, but their maximum clinging capability and mechanisms of attachment are not well understood. While some arboreal salamanders possess prehensile tails, salamanders lack many morphological adaptations for attachment, such as claws, toe pads, and fibrillar adhesive pads. Maximum cling performance and surface area of attachment were measured, and the adhesive capability of …

Measuring Quality Of Life In Patients With Rotator Cuff Disorders, Rochelle Furtado

Electronic Thesis and Dissertation Repository

Rotator cuff disorders (RCDs) are a common musculoskeletal problem with a higher prevalence in women and after the age of 60. Due to the increasing need for patient-centered care, researchers have been directed towards the use of patient reported outcomes (PROs) to evaluate the progress of patient recovery, as the experience varies across individuals.

Recently, the Western Ontario Rotator Cuff Index was reduced in items to create the shortened version of the Western Ontario Rotator Cuff Index (Short-WORC). However, the Short-WORC’s psychometrics have yet to be evaluated. Therefore, this mixed-methods thesis aimed to evaluate the psychometric properties of the Short-WORC …

Improved Orthopaedic Repairs Through Mechanically Optimized, Adhesive Biomaterials, Stephen Wheeler Linderman

McKelvey School of Engineering Theses & Dissertations

Despite countless surgical advances over the last several decades refining surgical approaches, repair techniques, and tools to treat tendon and tendon-to-bone injuries, we are still left with repair solutions that rely on fairly crude underlying mechanical principles. Musculoskeletal soft tissues have evolved to transfer high loads by optimizing stress distribution profiles across the tissue at each length scale. However, instead of mimicking these natural load transfer mechanisms, conventional suture approaches are limited by high load transfer across only a small number of anchor points within tissue. This leads to stress concentrations at anchor points that often cause repair failure as …

Its Skin Is My Skin, Bryan Page

Graduate School of Art Theses

This text examines the complexity of attempting to empathize with bodies that are vastly othered from my own. This broad yet nuanced subject crosses epistemological boundaries and complicates the dualities between both the mind and body, and between the corporeal and the virtual. My desire to better understand the conditions of another’s experience originates from a painful traumatic loss which caused me to feel isolated and incomplete. In response to this suffering, I long to emotionally connect with other beings and create artwork that attempts to bridge the qualia of individual experience.

I am interested in the capacity (or lack …

Quantitative Evaluation Of Geared Manual Wheelchair Mobility In Individuals With Spinal Cord Injury: An Integrative Approach, Omid Jahanian

Theses and Dissertations

The purpose of this dissertation is to quantify the effects of using geared wheelchair wheels on upper extremity biomechanics and energy expenditure during functional mobility tasks in individuals with spinal cord injury (SCI). The effects of using geared wheels on hand-rim biomechanics, glenohumeral joint dynamics, and shoulder muscle activity were investigated during manual wheelchair propulsion over tiled and carpeted level-floors and up a ramp in low gear (1.5:1) and standard gear (1:1) conditions. The results for the hand-rim biomechanics indicated that regardless of the terrain, using the geared wheels in the low gear condition significantly decreased the propulsion speed, stroke …

Validation Of A 5-Minute Vpc Test To Assess And Compare Cognitively Intact Individuals And Individuals With Cognitive Impairments, Spencer Smith

Graduate Theses and Dissertations

The prevalence of cognitive impairments in the older adult population is growing. Finding treatment solutions to impede a cognitive decline can possibly lead to fewer cases of mild cognitive impairment, dementia, and Alzheimer’s disease. A Visual Paired Comparison (VPC) could serve as a tool to predict, monitor, and regulate people who are susceptible to a cognitive decline. The purpose of this study was to 1) to determine the validity of the Neurotrack 5-minute VPC test with the Neurotrack 30-minute VPC test, 2) to determine the test-retest reliability of the Neurotrack 5-minute VPC test, 3) to compare Neurotrack 5-minute VPC scores …

Kinetic And Kinematic Characteristics Of Accentuated Eccentric Loading, John Wagle

Electronic Theses and Dissertations

The current investigation was an examination of the kinetic and kinematic characteristics of the back squat using accentuated eccentric loading (AEL) and cluster set programming strategies. Trained male subjects (age = 26.1 ± 4.1 years, height = 183.5 ± 4.3 cm, body mass = 92.5 ± 10.5 kg, back squat to body mass ratio = 1.8 ± 0.3) volunteered to complete four different load condition sessions involving traditionally loaded straight sets (TL), traditionally loaded cluster sets (TLC), AEL cluster sets (AEC), and AEL straight sets where only the first repetition of each set used eccentric overload (AEL1). The use of …

The Effects Of Shoe Type On Biomechanical And Physiological Responses To Stepping And Inclined Walking, Ashley L. Vansumeren

All NMU Master's Theses

The purpose of this study was to examine the effect of hiking shoes and hiking boots on the biomechanical responses to a stepping task and physiological responses to an inclined walking task. Participants (n = 16) performed six two minute stepping trials at a stepping rate of 72 bpm; three trials in hiking boots and three trials in hiking shoes. Following the stepping task, participants (n = 19) walked at 3.0 mph and 10% grade for five minutes in hiking shoes and hiking boots. Lower limb joint angles and moments were calculated using Visual 3D. Physiological data was averaged over …

The Effects Of Injury On Running Status And Gait Biomechanics, Kristyne Wiegand

UNLV Theses, Dissertations, Professional Papers, and Capstones

Over the past several decades, endurance running has grown steadily as a popular form of physical activity. Running is easily accessible, does not require expensive equipment, and can be performed without specific skill training. Individuals who run also experience health benefits like increased cardiovascular health and reduced risk of all-cause morbidity. Despite these benefits, running is also associated with high rates of musculoskeletal injury. Although researchers have attempted to identify injury risks and mitigate the incidence of running injury, there is still no consensus as to why runners become injured. Research has also attempted to identify biomechanical movement patterns that …

Validity And Reliability Of A 5-Minute Web-Camera Based Eye Tracking Test To Assess Visual Memory And Cognition, Emily Bates

Graduate Theses and Dissertations

There are approximately 5.7 million Americans currently living with Alzheimer’s Disease (AD). Early detection of cognitive impairment allows for earlier treatment, potentially slowing or halting cognitive decline. A 30-min web-camera eye tracking assessment (30-min VPC) has been validated as a tool to predict AD risk. However, a shorter version would allow for greater scalability and improve user experience. The purpose of this study was to: 1) determine the validity of the 5-minute web-camera based VPC test with the 30-min test, 2) determine the test-retest reliability of the 5-min test, 3) compare the 5-minute test scores of cognitively intact adults (18-39 …

Comparative Plasma Proteomics In Muscle Atrophy Induced By Cancer Cachexia And Hindlimb Unloading, Kirsten Rene Dunlap

Graduate Theses and Dissertations

Introduction: Muscle atrophy results from a dysfunction in protein turnover that leads to loss of mass and function and occurs concurrently with multiple pathologies such as cancer and extended bed rest. Atrophy reduces overall quality of life while increasing morbidity and mortality. Currently, efficacious therapeutic interventions to treat and prevent muscle wasting in all its forms are lacking, however if conserved mechanisms can be identified between wasting conditions, this would aid in the development of multipurpose therapeutics to ameliorate this pathology. Purpose: To examine circulating factors present across atrophic pathologies. Methods: 35 male C57BL/6J mice were assigned to hindlimb unloading …

Comparing Feeding Accuracy Between High And Low Predation Trinidad Guppies, Lydia J. Bonnell

Honors College Theses

Efficient feeding accuracy could increase an organism’s survival. Although local adaptation in Trinidad guppies is common, the effects on accuracy are unknown. Guppies were wild caught in 2015 and 2017, filmed while capturing prey. Accuracy wasn’t different within samples but differed across samples, possibly due to the prey types used.