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Full-Text Articles in Life Sciences
Treatment Of Hiv-Infected Individuals With The Histone Deacetylase Inhibitor Panobinostat Results In Increased Numbers Of Regulatory T Cells And Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses, Christel Rothe Brinkmann, Jesper Falkesgaard Højen, Thomas Aagaard Rasmussen, Anne Sofie Kjær, Rikke Olesen, Paul W. Denton, Lars Østergaard, Zhengyu Ouyang, Mathias Lichterfeld, Xu Yu, Ole Schmeltz Søgaard, Charles Dinarello, Martin Tolstrup
Treatment Of Hiv-Infected Individuals With The Histone Deacetylase Inhibitor Panobinostat Results In Increased Numbers Of Regulatory T Cells And Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses, Christel Rothe Brinkmann, Jesper Falkesgaard Højen, Thomas Aagaard Rasmussen, Anne Sofie Kjær, Rikke Olesen, Paul W. Denton, Lars Østergaard, Zhengyu Ouyang, Mathias Lichterfeld, Xu Yu, Ole Schmeltz Søgaard, Charles Dinarello, Martin Tolstrup
Paul W. Denton
Histone deacetylase inhibitors (HDACi) modulate the transcriptional activity of all cells, including innate and adaptive immune cells. Therefore, we aimed to evaluate immunological effects of treatment with the HDACi panobinostat in HIV-infected patients during a clinical phase IIa latency reversal trial. Using flow cytometry, we investigated changes in T cell activation (CD69, CD38, HLA-DR) and the expression of CD39 and CTLA4 on regulatory T cells (Tregs). Whole-blood stimulations were performed and cytokine responses measured using Luminex. Gene expression in purified peripheral blood mononuclear cells (PBMCs) was evaluated using an Affymetrix HTA 2.0 gene chip. We found that proportions of CD4+ …
Tissue-Specific Transcriptome For Poeciliopsis Prolifica Reveals Evidence For Genetic Adaptation Related To The Evolution Of A Placental Fish, Nathaniel K. Jue, Robert J. Foley, David N. Reznick, Rachel J. O'Neill, Michael J. O'Neill
Tissue-Specific Transcriptome For Poeciliopsis Prolifica Reveals Evidence For Genetic Adaptation Related To The Evolution Of A Placental Fish, Nathaniel K. Jue, Robert J. Foley, David N. Reznick, Rachel J. O'Neill, Michael J. O'Neill
Nathaniel Jue
Transcriptome Analysis Reveals Potential Mechanisms Underlying Differential Heart Development In Fast- And Slow-Growing Broilers Under Heat Stress, Jibin Zhang, Carl J. Schmidt, Susan J. Lamont
Transcriptome Analysis Reveals Potential Mechanisms Underlying Differential Heart Development In Fast- And Slow-Growing Broilers Under Heat Stress, Jibin Zhang, Carl J. Schmidt, Susan J. Lamont
Jibin Zhang
Differential Expression Of Cyb5a In Chinese And European Pig Breeds Due To Genetic Variations In The Promoter Region..Pdf, Ying Bai, Jibin Zhang, Y Xue, Yl Peng, Gang Chen, Meiying Fang
Differential Expression Of Cyb5a In Chinese And European Pig Breeds Due To Genetic Variations In The Promoter Region..Pdf, Ying Bai, Jibin Zhang, Y Xue, Yl Peng, Gang Chen, Meiying Fang
Jibin Zhang