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Full-Text Articles in Life Sciences
Mitochondrial Oma1 And Opa1 As Gatekeepers Of Organellar Structure/Function And Cellular Stress Response, Robert Gilkerson, Patrick De La Torre, Shaynah St. Vallier
Mitochondrial Oma1 And Opa1 As Gatekeepers Of Organellar Structure/Function And Cellular Stress Response, Robert Gilkerson, Patrick De La Torre, Shaynah St. Vallier
Biology Faculty Publications and Presentations
Mammalian mitochondria are emerging as a critical stress-responsive contributor to cellular life/death and developmental outcomes. Maintained as an organellar network distributed throughout the cell, mitochondria respond to cellular stimuli and stresses through highly sensitive structural dynamics, particularly in energetically demanding cell settings such as cardiac and muscle tissues. Fusion allows individual mitochondria to form an interconnected reticular network, while fission divides the network into a collection of vesicular organelles. Crucially, optic atrophy-1 (OPA1) directly links mitochondrial structure and bioenergetic function: when the transmembrane potential across the inner membrane (ΔΨm) is intact, long L-OPA1 isoforms carry out fusion of the mitochondrial …
Early Embryology Of The Insect Oligotoma Saundersii (Embiidina) Using Targeted Genes As Developmental Landmarks, Omar Doria
Theses and Dissertations - UTB/UTPA
Embiidina, or "webspinners", is a small, sexually dimorphic, polyneopterous insect order and is the only order to spin silk throughout their life cycle. Unique morphological features and the phylogenetic position of Embiidina make it an attractive subject for study of the evolution and development of the insect body plan and the origin of novel morphological features. Oligotoma saundersii is easily cultured and a viable laboratory organism. It has a fairly standard short-germ embryogenesis process requiring 453 hours at 28°C with progressive development beginning in the anterior region. Preliminary work on targeted developmental genes has yielded small portions of seven genes. …