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Biological Activities Of Cu(Ii) And Hg(Ii) Complexes Of A Heptadentate Schiff Base Ligand, Emel Ergene, Hülya Si̇vas, Kadri̇ye Benkli̇
Biological Activities Of Cu(Ii) And Hg(Ii) Complexes Of A Heptadentate Schiff Base Ligand, Emel Ergene, Hülya Si̇vas, Kadri̇ye Benkli̇
Turkish Journal of Biology
Two metal complexes were synthesized as [Hg(L)](ClO_4)_2 and [Cu(L)](ClO_4)2 by the template reaction between 2,6-bis(2 aminothiophenoxymethyl)pyridine and 2,2'-bipyridine-6,6'-dicarboxaldehyde in the presence of Hg(II) and Cu(II) perchlorate salts. The structures of the compounds were elucidated by IR, 1H-NMR, MASS, and Elemental Analyses values. Cytotoxicity of the compounds were investigated by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay in normal and cancerous rat fibroblasts. Both compounds showed cytotoxicity on 2 cell lines as a dose-dependent manner. Compound [Hg(L)](ClO_4)_2 was more cytotoxic than [Cu(L)](ClO_4)2. Apoptotic activity of compounds was evaluated by acridine orange staining and DNA fragmentation assay. Both cell lines exposed to the compounds exhibited …