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Full-Text Articles in Life Sciences
Role Of Secretory Leukocyte Protease Inhibitor In Urinary Tract Infection, Anne Rosen
Role Of Secretory Leukocyte Protease Inhibitor In Urinary Tract Infection, Anne Rosen
Arts & Sciences Electronic Theses and Dissertations
Urinary tract infections (UTIs) affect 150 million people per year worldwide and can be difficult to diagnose and treat leaving room for other biomarkers to be used to define an infection. Secretory leukocyte protease inhibitor (SLPI), an antimicrobial protein also with antiprotease and anti-inflammatory properties, may be involved in host response to UTI. Here we use an established UPEC-UTI model to infect female Slpi knockout and wild type mice to show SLPI plays a role in microbial ecology of the bladder. Bacterial abundance is altered in urinary tracts and is positively correlated with SLPI in urine of wild type mice. …
Microbiome Analyses Demonstrate Specific Communities Within Five Shark Species, Rachael Storo, Cole Easson, Mahmood S. Shivji, Jose V. Lopez
Microbiome Analyses Demonstrate Specific Communities Within Five Shark Species, Rachael Storo, Cole Easson, Mahmood S. Shivji, Jose V. Lopez
Biology Faculty Articles
Profiles of symbiotic microbial communities (“microbiomes”) can provide insight into the natural history and ecology of their hosts. Using high throughput DNA sequencing of the 16S rRNA V4 region, microbiomes of five shark species in South Florida (nurse, lemon, sandbar, Caribbean reef, and tiger) have been characterized for the first time. The microbiomes show species specific microbiome composition, distinct from surrounding seawater. Shark anatomical location (gills, teeth, skin, cloaca) affected the diversity of microbiomes. An in-depth analysis of teeth communities revealed species specific microbial communities. For example, the genus Haemophilus, explained 7.0% of the differences of the teeth microbiomes …