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Gene Annotation Of The Hypothetical Protein-Coding Genes Of Yersinia Pestis, Bethany Wilkinson, Celestino Velasquez
Gene Annotation Of The Hypothetical Protein-Coding Genes Of Yersinia Pestis, Bethany Wilkinson, Celestino Velasquez
Research Symposium
Technological advances within the past two decades have allowed researchers the capacity to sequence and analyze any genome. However, while many organisms have had their genomes sequenced, hardly any have been manually interpreted to propose the organism’s hypothetical protein-coding genes’ functions. The primary amino acid sequences of the organism’s genes can be used to offer functions for the organism’s proteins. Online programs such as BLAST, T-COFFEE, MUSCLE, TMHMM, SignalP, Phobius, and PSORTb, identify several properties such as conserved domains, protein families, protein conformations, signal peptides, and transmembrane regions of the sequences. These elements can be examined to provide insight into …
Gene Annotation Of The Hypothetical Protein-Coding Genes Of Coxiella Burnetii, Jason Salvato, Celestino Velasquez
Gene Annotation Of The Hypothetical Protein-Coding Genes Of Coxiella Burnetii, Jason Salvato, Celestino Velasquez
Research Symposium
Genetic information of organisms and microorganisms has become readily accessible due to advances in genomic sequencing and bioinformatic technology. Despite these advances, there are numerous organisms with genome sequences that have yet to be annotated. Many of these genome sequences require manual annotation, which can uncover hypothetical protein-coding genes. Through the use of publicly available online bioinformatics tools, such as BLAST, T- COFFEE, TMHMM, SignalP, Phobius, and PSORTb, the functions of hypothetical protein- coding genes can be predicted from primary amino acid sequences. Two clusters of properties that aid in determining and predicting the hypothetical genes involve sequence similarity and …