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Acetaminophen Potentiates Fear Processing: A Comparison Between Ancestral And Modern Threats, Andrew Gallup, Brianda Gagnon, Gillian Perry, Omar T. Eldakar

Biology Faculty Articles

The painkilling medication acetaminophen produces a variety of unintended psychological effects. In particular, it has been shown to diminish varied forms of psychological distress by attenuating neural activity in the cerebral cortex and enhancing the signaling of serotonin. As a result, this over-the-counter medication appears to dampen overall affective processing and has been termed “an all-purpose emotion reliever.” However, this drug may not necessarily modify all emotions in the same manner. Specifically, fear processing occurs rapidly within the amygdala and is governed by serotonin. Thus, by blunting cortical activity and facilitating serotonergic action, acetaminophen could in fact potentiate reactions to …