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Human Cst (Ctc1-Stn1-Ten1) Promotes Topbp1 Stability And Chk1 Phosphorylation In Response To Telomere Dysfunction And Global Replication Stress, Stephanie Michelle Ackerson
Human Cst (Ctc1-Stn1-Ten1) Promotes Topbp1 Stability And Chk1 Phosphorylation In Response To Telomere Dysfunction And Global Replication Stress, Stephanie Michelle Ackerson
Theses and Dissertations
Genomic DNA is constantly damaged by both internal and external genotoxins and cellular processes. A consequence of unrepaired or misrepaired DNA damage is genome instability, a hallmark of cancer and numerous other diseases. Eukaryotic cells have developed complex mechanisms to repair DNA damage, which is collectively referred to as a DNA damage response (DDR). CST (CTC1-STN1-TEN1) is a heterotrimeric, RPA-like protein complex that binds to single stranded (ss)DNA. In humans, CST functions in the replication and maintenance of telomeres, structures found at the ends of linear chromosomes, as well as non-telomeric DNA. Previous studies showed that deletion of the largest …