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Full-Text Articles in Life Sciences
Understanding The Metabolic Regulation Of Trained Immunity By Palmitic Acid, Khaleda Aqaei, Brooke A. Napier
Understanding The Metabolic Regulation Of Trained Immunity By Palmitic Acid, Khaleda Aqaei, Brooke A. Napier
McNair Symposium
Sepsis is an inflammatory disease that occurs when the body’s response to an infection becomes dysregulated, and infection-fighting processes of the body damage tissues via inflammation, resulting in organ failure and death. Currently, the role for diet in regulating sepsis susceptibility and severity is not fully understood. The Western Diet (WD), the most prevalent diet worldwide, is high in saturated fatty acids (SFAs) and sucrose, and low in fiber. Previously, we have used a lipopolysaccharide (LPS)-induced sepsis mouse model to show that mice fed a Western Diet (WD) or a diet enriched only in SFAs (Ketogenic Diet; KD), experience increased …
Hybrid-Lipid Coated Silver Nanoparticles As An Antimicrobial, Alexandria Murphy, Marilyn R. Mackiewicz, Michael S. Bartlett
Hybrid-Lipid Coated Silver Nanoparticles As An Antimicrobial, Alexandria Murphy, Marilyn R. Mackiewicz, Michael S. Bartlett
McNair Symposium
Silver has been known to be an antimicrobial for hundreds of years, but wasn’t thought to be useful in the medical field until the 1960’s. In more recent years people have been designing different methods of synthesis for silver nanoparticles, yet none of these methods prevent the oxidized silver (Ag+), which is toxic. As the use of silver nano materials for antimicrobial activity has expanded there has been an increase in interest in the medical field, and how silver nanoparticles can be used as an antimicrobial without having toxic effects. While there is a large availability of silver nanoparticles (AgNp’s) …
The Effect Of Apremilast On Circadian Rhythm In The Ventral Tegmental Area, Courtney Ledford, Angela Ozburn
The Effect Of Apremilast On Circadian Rhythm In The Ventral Tegmental Area, Courtney Ledford, Angela Ozburn
McNair Symposium
Chronic binge drinking negatively impacts society and is a leading cause of preventable deaths. The purpose of the experiment is to determine if regulation of circadian rhythms in the ventral tegmental area (VTA) will contribute to less ethanol consumption. The VTA plays a major role in addiction. A simple genetic animal model examines iHDID-1 mice and their binge-like drinking intake. The mice undergo Drinking in the Dark (DID) for 6 weeks prior to administration of apremilast or saline treatment at weeks 7 and 8. The mice are exposed to DID and sacrificed at two separate time points (ZT 3 and …
Efficacy Of Curcumin In Asthma: A Systematic Review And Meta Analysis, Tabitha Grow, Adam Sadowski
Efficacy Of Curcumin In Asthma: A Systematic Review And Meta Analysis, Tabitha Grow, Adam Sadowski
McNair Symposium
Over 23 million people are affected by asthma in the United States and 262 million individuals globally. Asthma, if poorly controlled, is associated with significant morbidity as well as increased risk for mortality. Asthma involves several complex inflammatory pathways and processes including an increase in immune cell activation. Curcumin, the active constituent found in turmeric, has been studied in numerous in-vivo and in-vitro studies to generate anti-inflammatory effects in pulmonary diseases and, more recently, an increase in clinical data has become available. Since the most recent review assessing the role of curcumin in pulmonary disorders, additional clinical trials have been …