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Interaction Of Certain Monoterpenoid Hydrocarbons With The Receptor Binding Domain Of 2019 Novel Coronavirus (2019-Ncov), Transmembrane Serine Protease 2 (Tmprss2), Cathepsin B, And Cathepsin L (Catb/L) And Their Pharmacokinetic Properties, Erman Sali̇h İsti̇fli̇, Arzuhan Şihoğlu Tepe, Cengi̇z Sarikürkcü, Bektaş Tepe
Interaction Of Certain Monoterpenoid Hydrocarbons With The Receptor Binding Domain Of 2019 Novel Coronavirus (2019-Ncov), Transmembrane Serine Protease 2 (Tmprss2), Cathepsin B, And Cathepsin L (Catb/L) And Their Pharmacokinetic Properties, Erman Sali̇h İsti̇fli̇, Arzuhan Şihoğlu Tepe, Cengi̇z Sarikürkcü, Bektaş Tepe
Turkish Journal of Biology
As of June 2020, the coronavirus disease 19 (COVID-19) caused by the 2019 new type coronavirus (2019-nCoV) infected more than 7,000,000 people worldwide and caused the death of more than 400,000 people. The aim of this study was to investigate the molecular interactions between monoterpenoids and spike protein of 2019-nCoV together with the cellular proteases [transmembrane serine protease 2 (TMPRSS2), cathepsin B (CatB), and cathepsin L (CatL)]. As a result of the relative binding capacity index (RBCI) analysis, carvone was found to be the most effective molecule against all targets when binding energy and predicted (theoretical) IC50 data were evaluated …