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Full-Text Articles in Life Sciences
Neuromodulation With Electromagnetic Stimulation For Seizure Suppression: From Electrode To Magnetic Coil, Hui Ye, Stephanie Kaszuba
Neuromodulation With Electromagnetic Stimulation For Seizure Suppression: From Electrode To Magnetic Coil, Hui Ye, Stephanie Kaszuba
Biology: Faculty Publications and Other Works
Non-invasive brain tissue stimulation with a magnetic coil provides several irreplaceable advantages over that with an implanted electrode, in altering neural activities under pathological situations. We reviewed clinical cases that utilized time-varying magnetic fields for the treatment of epilepsy, and the safety issues related to this practice. Animal models have been developed to foster understanding of the cellular/molecular mechanisms underlying magnetic control of epileptic activity. These mechanisms include (but are not limited to) (1) direct membrane polarization by the magnetic field, (2) depolarization blockade by the deactivation of ion channels, (3) alteration in synaptic transmission, and (4) interruption of ephaptic …
Contributions Of Vps35 Mutations To Parkinson’S Disease, Abir A. Rahman, Brad E. Morrison
Contributions Of Vps35 Mutations To Parkinson’S Disease, Abir A. Rahman, Brad E. Morrison
Biology Faculty Publications and Presentations
Parkinson’s Disease (PD) is a multi-system neurodegenerative disease where approximately 90% of cases are idiopathic. The remaining 10% of the cases can be traced to a genetic origin and research has largely focused on these associated genes to gain a better understanding of the molecular and cellular pathogenesis for PD. The gene encoding vacuolar protein sorting protein 35 (VPS35) has been definitively linked to late onset familial PD following the identification of a point mutation (D620N) as the causal agent in a Swiss family. Since its discovery, numerous studies have been undertaken to characterize the role of VPS35 in cellular …