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Effects Of The Nerve During The Dedifferentiative Phase Of Limb Regeneration In The Mexican Axolotl, Ambystoma Mexicanum, Roberta Gail Wald

Dissertations and Theses

It is known that nerves are particularly critical during the early or dedifferentiative phase of limb regeneration. During this period in the innervated limb, cells just proximal to the amputation surface dedifferentiate, migrate to the limb tip, and undergo mitosis. These processes give rise to a population of undifferentiated mesenchymatous cells capable of redifferentiating into the missing components of the newly forming regenerate. The consequences of denervation stand in stark contrast to the normal events occurring in the innervated limb, because neither a blastema nor a regenerate forms.

Results from this study indicate that during the early portion of the …