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Enhanced Neurogenesis In Subventricular Zone Of Rats That Voluntarily Ingest Fluoxetine And Simavastatin Combination Treatment, Tiffany L. Flannery
Enhanced Neurogenesis In Subventricular Zone Of Rats That Voluntarily Ingest Fluoxetine And Simavastatin Combination Treatment, Tiffany L. Flannery
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Stroke is one of the leading causes of deaths as the risk factors, both controllable and uncontrollable, are many. We first concentrated on a stress-free way to deliver the drugs. Our preference was to have the animals ingest the drugs, which led us to a reliable method for orally administering medication to the animal models. Using three different drug combinations, we tested the effects on neurogenesis without stroke. We found the drug combination of Fluoxetine/Statin/Ascorbic acid increases neurogenesis 19 fold when compared with control. Lastly, we looked at the gene changes in the cortex of the animal models that had …