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Full-Text Articles in Life Sciences
Characterization Of The Structure, Function And Assembly Of The Drrab Antibiotic Efflux Pump In Streptomyces Peucetius, Divya Kishore Rao
Characterization Of The Structure, Function And Assembly Of The Drrab Antibiotic Efflux Pump In Streptomyces Peucetius, Divya Kishore Rao
Biology Dissertations
ATP binding cassette (ABC) transporters constitute one of the largest families of transport proteins. The occurrence of multidrug resistance (MDR) in human cancer cells has been correlated with the over expression of human ABC, P-glycoprotein (Pgp). Streptomyces peucetius produces two anticancer agents, doxorubicin and daunorubicin, that belong to the anthracycline family of antibiotics. The organism is self-resistant to the potent effects of the antibiotics it produces due to the action of an efflux pump, DrrAB. Both Pgp and DrrAB carry out similar functions, but in two different cell types. An understanding of the bacterial drug transporter DrrAB is thus expected …
Interpretation And Prediction Of Structural And Energetic Factors Controlling Abc Transporters, Xianfeng Chen
Interpretation And Prediction Of Structural And Energetic Factors Controlling Abc Transporters, Xianfeng Chen
Biology Dissertations
ATP Binding Cassette (ABC) transporters are trans-membrane proteins that exist in all phyla. Mutations in this family of proteins can cause inherited diseases like Cystic Fibrosis. ABC transporters consist of dimers of nucleotide binding domains (NBDs) and transmembrane domains (TMDs). NBDs regulate ABC transporters by binding to and hydrolyzing ATP. Although NBD-ATP interactions, NBD-TMD interactions and NBD-water interactions are known to be crucial to the function of these proteins, it is still not clear what structural and energetic factors are involved in the NBD-NTP interactions, how NBD and TMD interact with each other, how water is involved in the functions …