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Full-Text Articles in Life Sciences
Demasculinization And Feminization Of Male Gonads By Atrazine: Consistent Effects Across Vertebrate Classes, Krista A. Mccoy
Demasculinization And Feminization Of Male Gonads By Atrazine: Consistent Effects Across Vertebrate Classes, Krista A. Mccoy
Integrative Biology Faculty and Staff Publications
Atrazine is the most commonly detected pesticide contaminant of ground water, surface water, and precipitation. Atrazine is also an endocrine disruptor that, among other effects, alters male reproductive tissues when animals are exposed during development. Here, we apply the nine so-called “Hill criteria” (Strength, Consistency, Specificity, Temporality, Biological Gradient, Plausibility, Coherence, Experiment, and Analogy) for establishing cause–effect relationships to examine the evidence for atrazine as an endocrine disruptor that demasculinizes and feminizes the gonads of male vertebrates. We present experimental evidence that the effects of atrazine on male development are consistent across all vertebrate classes examined and we present a …
Rhythmic Leptin Is Required For Weight Gain From Circadian Desynchronized Feeding In The Mouse, Deanna M. Arble, Martha H. Vitaterna, Fred W. Turek
Rhythmic Leptin Is Required For Weight Gain From Circadian Desynchronized Feeding In The Mouse, Deanna M. Arble, Martha H. Vitaterna, Fred W. Turek
Biological Sciences Faculty Research and Publications
The neuroendocrine and metabolic effects of leptin have been extensively researched since the discovery, and the later identification, of the leptin gene mutated within the ob/ob mouse. Leptin is required for optimal health in a number of physiological systems (e.g. fertility, bone density, body weight regulation). Despite the extensive leptin literature and many observations of leptin’s cyclical pattern over the 24-hour day, few studies have specifically examined how the circadian rhythm of leptin may be essential to leptin signaling and health. Here we present data indicating that a rhythmic leptin profile (e.g. 1 peak every 24 hours) leads to excessive …
Ampk Directly Inhibits Ndpk Through A Phosphoserine Switch To Maintain Cellular Homeostasis, R. U. Onyenwoke, L. J. Forsberg, L. Liu, Tyisha Williams, O. Alzate, J. E. Brenman
Ampk Directly Inhibits Ndpk Through A Phosphoserine Switch To Maintain Cellular Homeostasis, R. U. Onyenwoke, L. J. Forsberg, L. Liu, Tyisha Williams, O. Alzate, J. E. Brenman
Biology Faculty Research
AMP-activated protein kinase (AMPK) is a key energy sensor that regulates metabolism to maintain cellular energy balance. AMPK activation has also been proposed to mimic benefits of caloric restriction and exercise. Therefore, identifying downstream AMPK targets could elucidate new mechanisms for maintaining cellular energy homeostasis. We identified the phosphotransferase nucleoside diphosphate kinase (NDPK), which maintains pools of nucleotides, as a direct AMPK target through the use of two-dimensional differential in-gel electrophoresis. Furthermore, we mapped the AMPK/NDPK phosphorylation site (serine 120) as a functionally potent enzymatic “off switch” both in vivo and in vitro. Because ATP is usually the most abundant …