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Full-Text Articles in Life Sciences
The Relationship Between Autoimmunity And Polyautoimmunity, David Schon
The Relationship Between Autoimmunity And Polyautoimmunity, David Schon
The Science Journal of the Lander College of Arts and Sciences
Autoimmune disease refers to a systemic immune response by the body against its own healthy tissue and cells. This results in various non-specific and systemic inflammatory processes that evolve into more than 100 individual diseases. Numerous biological similarities exist between the different pathophysiological pathways, including biochemical cascades and inflammasome mediators. This paper aims to investigate whether contracting one form of autoimmune disease can lead to the development of polyautoimmunity and multiple autoimmune syndrome. Scientists have identified chronic levels of high stress as a contributor to higher levels of C-reactive protein and several immune modulating interleukins, which can lead to both …
The Riddle Of The Fetal Allograft, Rachel Tepper
The Riddle Of The Fetal Allograft, Rachel Tepper
The Science Journal of the Lander College of Arts and Sciences
The immunological paradox of nurturing a fetus with paternal antigens poses some perplexing questions. Peter Medawar, an immunologist, asked at a lecture, “How does the pregnant mother contrive to nourish within itself, for many weeks or months, a fetus that is an antigenically foreign body?” Researchers have since then struggled to answer this question. The research on this topic has led to a few general hypotheses that try to explain this phenomenon. The downregulation of T cells toward paternal alloantigens is an accepted hypothesis. Another hypothesis discusses the significance of the decidua and its ability to impair dendritic cells, which …
Sex Effect On The Correlation Of Immunoglobulin G Glycosylation With Rheumatoid Arthritis Disease Activity, Altan Ercan
Sex Effect On The Correlation Of Immunoglobulin G Glycosylation With Rheumatoid Arthritis Disease Activity, Altan Ercan
Turkish Journal of Biology
Rheumatoid arthritis (RA) is a chronic autoimmune disease which affects females more than males with a presence of autoantibodies. Immunoglobulin G (IgG) produced by adaptive arm has 2 functional domains, Fc and Fab. The Fc domain binds Fc gamma receptors and C1q proteins of the innate arm. Therefore, the IgG Fc domain serves as a bridge between the innate and adaptive arms and is regulated by an evolutionarily conserved N-glycosylation with variable structures. These glycans are classified as agalactosylated G0, monogalactosylated G1, and digalactosylated G2, which are further modified by core-fucosylation (F) and bisecting N-acetylglucosamine (B) moieties such as G0F …
Possible Mechanisms That Protect The Fetus From Maternal Rejection, Adina Ziemba-Goldfarb
Possible Mechanisms That Protect The Fetus From Maternal Rejection, Adina Ziemba-Goldfarb
The Science Journal of the Lander College of Arts and Sciences
There is no other foreign tissue transplant that has such a strongly parasitic relationship with its human host as the fetus. Although the fetus contains paternal genes, is completely tolerized by its maternal host in almost all pregnancies. This presents an immunological paradox and has generated a lot of attention from leading researchers in the reproductive and immunology fields. This paper reviews the leading explanations for this paradox; that it is attributed to a detailed mechanism of the maternal and fetal immune system in which tryptophan suppresses T-cells from attacking specific paternal cells, while maintaining a strong immune response against …
Mathematical Modeling And Analysis Of Leukemia: Effect Of External Engineered T Cells Infusion, Manju Agarwal, Archana S. Bhadauria
Mathematical Modeling And Analysis Of Leukemia: Effect Of External Engineered T Cells Infusion, Manju Agarwal, Archana S. Bhadauria
Applications and Applied Mathematics: An International Journal (AAM)
In this paper, a nonlinear model is proposed and analyzed to study the spread of Leukemia by considering the effect of genetically engineered patients T cells to attack cancer cells. The model is governed by four dependent variables namely; naive or susceptible blood cells, infected or dysfunctional blood cells, cancer cells and immune cells. The model is analyzed by using the stability theory of differential equations and numerical simulation. We have observed that the system is stable in the local and global sense if antigenicity rate or rate of stimulation of immune cells is greater than a threshold value dependent …
Immunological Pathogenesis Of Endolymphatic Hydrops And Its Relation To Meniere's Disease, S. Tomiyama, T. Yagi, M. Sakagami, K. Fukazawa
Immunological Pathogenesis Of Endolymphatic Hydrops And Its Relation To Meniere's Disease, S. Tomiyama, T. Yagi, M. Sakagami, K. Fukazawa
Scanning Microscopy
This study was designed to investigate an immunologically induced endolymphatic hydrops (ELH) and to focus on the issue of its pathogenesis in relation to Meniere's disease. The time course of ELH was evaluated by light microscopy in a 2-hour to 7-month period following direct antigen challenge to the endolymphatic sac (ELS) in systemically pre-sensitized guinea pigs. ELH began to appear in the vestibule and the basal turn 5-7 hours after inner ear challenge and developed gradually. During the interval from the second day to the first week, ELH rapidly developed in all the cochlear turns and reached a maximum size. …