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Full-Text Articles in Life Sciences
Cytotoxicity And Antibiofilm Activity Of Sio2/Cellulose Derivative Hybrid Materials Containing Silver Nanoparticles, Tsvetelina Angelova, Nadezhda Rangelova, Veselina Uzunova, Nelly Georgieva, Tonya Andreeva, Albena Momchilova, Rumiana Tzoneva, Rudolf Müller
Cytotoxicity And Antibiofilm Activity Of Sio2/Cellulose Derivative Hybrid Materials Containing Silver Nanoparticles, Tsvetelina Angelova, Nadezhda Rangelova, Veselina Uzunova, Nelly Georgieva, Tonya Andreeva, Albena Momchilova, Rumiana Tzoneva, Rudolf Müller
Turkish Journal of Biology
Hybrid materials based on tetraethyl orthosilicate (TEOS), hydroxypropyl cellulose (HPC), or hydroxypropyl methyl cellulose (HPMC) with silver nanoparticles were synthesized. They were analyzed and characterized using differential thermal analysis and thermogravimetry, atomic force microscopy, and static contact angle measurements. It was experimentally demonstrated that the silver-doped hybrid materials have pronounced antibacterial behavior by studying the reduction of Pseudomonas aeruginosa PAO1 biofilm formation on the tested materials. The results revealed biofilm reduction of 35.7% and 30% by SiO2/HPC/2.5% Ag and SiO2/HPMC/2.5% Ag hybrid materials, respectively, compared to the control. Cytotoxicity of examined materials and actin cytoskeleton organization of fibroblasts seeded on …
Apoptotic Induction Via Membrane/Dna Damage And Metabolic Inactivation By Synthetic Food Colorants In Allium Cepa Root Meristem, Prajitha Vazhangat, John Ernest Thoppil
Apoptotic Induction Via Membrane/Dna Damage And Metabolic Inactivation By Synthetic Food Colorants In Allium Cepa Root Meristem, Prajitha Vazhangat, John Ernest Thoppil
Turkish Journal of Biology
The present study investigates the cytotoxic and genotoxic effects of two frequently employed synthetic food colorants, lemon yellow and orange red, using an Allium cepa assay. Uptake of food colorants by root cells at different concentrations and varied exposures significantly altered the cytogenetic system, membrane integrity, mitochondrial function, root growth, and cell division. The food colorants induced significant DNA damage, micronucleus formation, and other severe chromosomal aberrations at genetic level and inhibited cell division as well as root growth. Severe DNA damage, membrane damage, and metabolic inactivation observed in the result are indicative of apoptotic cell death. These results confirm …
Cytotoxicity And Antiviral Activity Of Palladium(Ii) And Platinum(Ii) Complexes With 2-(Diphenylphosphino)Benzaldehyde 1-Adamantoylhydrazone, Vera Simic, Stoimir Kolarevic, Ilija Brceski, Dejan Jeremic, Branka Vukovic-Gacic
Cytotoxicity And Antiviral Activity Of Palladium(Ii) And Platinum(Ii) Complexes With 2-(Diphenylphosphino)Benzaldehyde 1-Adamantoylhydrazone, Vera Simic, Stoimir Kolarevic, Ilija Brceski, Dejan Jeremic, Branka Vukovic-Gacic
Turkish Journal of Biology
Metal coordination compounds have an important role in the development of novel drugs. Using the resazurin microtitration assay we assessed the cytotoxicity and antiviral activity of the ligand 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone and its Pd(II) and Pt(II) complexes. Cytotoxicity was tested in A549 human lung adenocarcinoma epithelial cells. We observed that the ligand displayed a more pronounced cytotoxic activity than the platinum-based drug, carboplatin. Morphological evaluation of A549 cells treated with the ligand by acridine orange and ethidium bromide double staining revealed the presence of signs of apoptosis. Antiviral activity against poliovirus type 1 was assessed by examination of the cytopathic effect …