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Full-Text Articles in Life Sciences
The Effects Of Dna Methyl Transferases On Antiaging Klotho Gene Expression, Eli̇f Çağlayan, Kadi̇r Turan
The Effects Of Dna Methyl Transferases On Antiaging Klotho Gene Expression, Eli̇f Çağlayan, Kadi̇r Turan
Turkish Journal of Biology
Several intracellular metabolic pathways in which multiple genes have a role affect the aging process. One important genetic factor associated with aging is klotho gene. In some recently published studies, klotho gene has also been associated with several types of cancer and identified as a tumor suppressor gene. Therefore, elucidation of the control of klotho gene expression has become more important. Results suggesting that the promoter region of human klotho gene could be epigenetically controlled by DNA methylation have been reported. In contrast, a study revealing whether a change in the expression level of DNMT enzymes in the cells affects …
A Matter Of Regeneration And Repair: Caspases As The Key Molecules, Şehnaz Bolkent, Füsün Öztay, Selda Oktayoğlu, Serap Sancar Baş, Ayşe Karatuğ
A Matter Of Regeneration And Repair: Caspases As The Key Molecules, Şehnaz Bolkent, Füsün Öztay, Selda Oktayoğlu, Serap Sancar Baş, Ayşe Karatuğ
Turkish Journal of Biology
Researchers have been focused on understanding the pathogenesis of human diseases. They have been working to find the roles of caspases in the balance between apoptosis, autophagy, pyroptosis, and necroptosis, and also in the regeneration of damaged tissue. At this point, besides their death-inducing roles, new findings indicate the role of caspases in proliferation for maintaining the viability of cells in response to signals from apoptotic cells. Recently, determining cell fate has also been identified among other functions of caspases. Findings indicate that caspases direct cellular pathways to cell differentiation by suppressing stem cell self-renewal. The common opinion about the …